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Synthetic Control Chemistry Lab
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A lab that uses the power of organic synthesis to create bioactive molecules and pharmaceuticals.
AboutAbout the lab
Precision synthetic organic chemistry leading the advancement of pharmaceutical sciences.
The Synthetic Control Chemistry Lab conducts basic research that follows life phenomena from the standpoint of synthetic organic chemistry, with the aim of creating superior pharmaceuticals.
Its central subject is the synthesis of biologically active compounds (mainly natural products).
In addition, the lab develops catalytic reactions for efficiently making pharmaceuticals and other compounds, and creates molecular tools to study how drugs act.
Research is carried out using not only experiments but also computational chemistry.
Key terms
- Natural product
- An organic compound produced by living organisms. It has a complex structure and often gives hints for new drugs.
- Asymmetric catalyst
- A catalyst that selectively makes one of two molecules that are mirror images of each other.
- Chemical biology
- A research field that uses molecules made by chemical methods to study life phenomena.
NewsLab news
Associate Professor Sasano concurrently holds a position as Project Associate Professor at Nara Institute of Science and Technology (cross-appointment)
A commemorative paper for Associate Professor Sasano's Pharmaceutical Society of Japan Award for Young Scientists was published in Chem. Pharm. Bull.
ResearchResearch themes
From the standpoint of synthetic organic chemistry, the lab conducts basic research that follows life phenomena in order to create superior pharmaceuticals. Centered on the synthesis of biologically active compounds, it aims to develop asymmetric catalysts that control reaction selectivity, and it also pursues chemical biology research using molecular tools that probe how drugs act.
*Illustrative imageDevelopment of Highly Selective Synthetic Methods
With the keywords "molecular catalysis," "redox control," and "asymmetric synthesis," the lab develops methods that support the synthesis of increasingly complex pharmaceuticals. It works on oxidation reactions using organocatalysts and oxidative molecular transformations using catalysts that combine organic molecules and metals.
*Illustrative imageSynthesis of Biologically Active Natural Products
The lab develops efficient synthetic methods for natural products that have complex structures and distinctive biological activity. By providing samples that can be used for detailed pharmacological studies, it carries out basic research that contributes to drug discovery.
*Illustrative imageDrug Discovery Research Using Cage Hydrocarbons
Focusing on adamantane and cubane, which are cage-shaped hydrocarbons, the lab develops synthetic methods to freely attach other structures to them and to make derivatives. It aims to broaden the range of three-dimensional molecules and apply them to drug development.
*Illustrative imageFunctional Analysis of Biologically Active Molecules
By chemically modifying bioactive molecules with units that can be used to analyze or control their function, the lab investigates their targets and actions. It uses biotin to identify target proteins, glutathione to increase water solubility, and alkyne tags to image living cells with Raman microscopy.
MembersFaculty
The members of the Synthetic Control Chemistry Lab are faculty, project researchers, students in the doctoral, master's, and undergraduate programs, and secretaries.As of 2026
- ProfessorYoshiharu Iwabuchi
- Associate ProfessorYusuke Sasano
- Assistant ProfessorShota Nagasawa
- Assistant ProfessorHiroyuki Yamakoshi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rotary evaporator” Y Chen / CC BY-SA 4.0 (cropped)
- Development of Highly Selective Synthetic Methods: “Organic Chemistry Lab 5 by marthou” Marthou / CC BY-SA 4.0 (cropped)
- Synthesis of Biologically Active Natural Products: “Scutellaria altissima Medicinal Plants Garden of UCLouvain” Marc Eylenbosch / CC BY-SA 4.0 (cropped)
- Drug Discovery Research Using Cage Hydrocarbons: “Adamantane 3D ball” Jynto (talk) / CC0 (cropped)
- Functional Analysis of Biologically Active Molecules: “Confocal Raman imaging microscope Witec alpha300” Sonjajnos / CC BY-SA 4.0 (cropped)
- Related lab (分子設計化学分野): “Vintage laboratory glassware” LukaszKatlewa / CC BY 4.0 (cropped)
- Related lab (反応制御化学分野): “Round bottom flask 1” Stephanie cheks / CC BY-SA 4.0 (cropped)
- Related lab (環境調和化学分野): “BuretteFumeHood” Walkerma / CC BY-SA 3.0 (cropped)
- Related lab (医薬資源化学分野): “Aspergillus clavatus petri dish” Dr. Hilliard F. Hardin, CDC / Public domain (cropped)
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