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29 labs · 5 student voices
Faculties at Kyoto University ›
Yasushi Ishihama, Professor
0 student voices
The Biomolecular Measurement field (Ishihama Lab) is built around analytical science and aims to uncover the functions of cells and molecules by measuring the molecules that make up living organisms. Using mass spectrometry, trace-level separation analysis, computational science, cell biology, and other approaches, the lab develops methodologies for proteome analysis and applies them to analyzing cell function and to drug development. For each field opened up by new technology, the lab aims to follow through to its biological applications.
ROBERT Martin, Program-Specific Associate Professor
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The basic functions of life, such as cell movement, growth, response to the environment, and energy metabolism, arise from extremely complex networks of interacting biomolecules. The Systems Microbiology field takes E. coli, a bacterium that also lives in the human gut, as a model and works to understand these networks as systems. E. coli turns out to lead a more sophisticated "social life" than previously thought, and the lab is exploring what that looks like.
Akira Hirasawa, Associate Professor
0 student voices
G protein-coupled receptors (GPCRs) are sensor molecules that relay information into the cell. They are often involved in disease and are one of the main targets of drugs. However, for many of them, the substance they bind to (the ligand) is unknown. The Pharmacogenomics and Genomic Drug Discovery field searches for the ligands of receptors whose ligands are unknown, and it discovered a new fatty acid receptor, GPR120. The lab has shown that GPR120 promotes hormone secretion when stimulated by dietary fatty acids, and that it is related to obesity in both mice and humans. Every year, undergraduate students are assigned to the lab for their graduation research.
Hiroaki Ohno, Professor
0 student voices
Most biomolecules and drugs are organic compounds, so a deep understanding of organic chemistry is essential for making drugs and using them correctly. Good drugs have already been developed for diseases that are easy to treat, leaving the diseases that are hard to treat. If compounds that are difficult to synthesize can be used in drug discovery, or if interactions between biomolecules that have been hard to regulate can be controlled, they could open the way to new drugs. The lab aims at drug discovery grounded in organic chemistry.
Masao Doi, Professor
0 student voices
Disease symptoms and the effects of drugs change periodically depending on the time of day set by the body clock. It is also known that when the circadian clock's function declines because of an irregular lifestyle or aging, a variety of diseases can occur. The lab aims to establish time-based pharmaceutical science grounded in biological rhythms. Creating drugs based on the new idea of adjusting the timing of the body clock could fundamentally improve diseases caused by circadian clock abnormalities.
Hideaki Kakeya, Professor
0 student voices
The "life, death, and differentiation" of cells is tightly controlled by factors that determine proliferation, differentiation, and cell death. Disruption of this regulation is thought to lead to diseases such as cancer, infectious diseases, heart disease, neurodegenerative diseases, immune disorders, and diabetes. Centered on natural products chemistry and medicinal chemistry, the lab pioneers new bioactive small molecules and uses them to carry out chemical biology research that uncovers how the "life, death, and differentiation" of cells is regulated. Several new bioactive molecules based on the lab's research results are already sold commercially as biochemical reagents.
Erina Kuranaga, Professor
0 student voices
The Tissue Formation Dynamics Lab (Kuranaga Lab) was launched in April 2023 in the Graduate School of Pharmaceutical Sciences. In the development of multicellular organisms, the body takes shape as many cells go through events such as proliferation, differentiation, adhesion, migration, and death. Programmed cell death has been found to do more than remove unneeded cells: it also helps regulate the proliferation and migration of surrounding cells. The lab investigates how these cell behaviors are coordinated to form tissues, by capturing events as they happen in real time inside living organisms.
Hiroshi Mamitsuka, Professor
0 student voices
The focus of life science research is shifting from analyzing the role of individual biomolecules to understanding how living systems work among many kinds of mixed molecules. A representative example is the pathway, a set of interactions among biomolecules. To uncover the molecular mechanisms of biological phenomena, such as metabolic pathways and signal transduction pathways, from diverse data, the lab develops many informatics methods grounded in computer science and statistics.
Ayuna Hattori, Associate Professor
0 student voices
The Cancer and Stem Cell Signaling Lab (Laboratory of Stem Cell Metabolic Regulation, Institute for Life and Medical Sciences) aims to clarify the mechanisms that determine stem cell fate. Stem cells are capable of self-renewal, proliferating while retaining pluripotency, and they maintain tissues by supplying new cells. Cancer tissues also contain self-renewing "cancer stem cells," which are involved in therapy resistance, metastasis, and recurrence, making them an effective therapeutic target. The lab aims to contribute to developing safe and effective treatment strategies for tissue regeneration, frailty, and cancer.
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