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Systems Microbiology Lab
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The lab studies E. coli colonies and biofilms as systems to explore the society of bacteria.
AboutAbout the lab
Bacteria have societies, too.
The basic functions of life, such as cell movement, growth, response to the environment, and energy metabolism, arise from extremely complex networks of interacting biomolecules.
The Systems Microbiology field takes E. coli, a bacterium that also lives in the human gut, as a model and works to understand these networks as systems.
E. coli turns out to lead a more sophisticated "social life" than previously thought, and the lab is exploring what that looks like.
Key terms
- Biofilm
- A community that bacteria form by gathering inside a matrix made of proteins and polysaccharides
- Omics
- A general term for research that comprehensively investigates genes, proteins, metabolites, and other molecules as a whole
- Colony
- A visible cluster formed as a single bacterium multiplies
ResearchResearch themes
The lab combines biochemistry, imaging, omics analysis, and data analysis to study the behavior of E. coli cells and populations.
*Illustrative imageBiofilm development and division of roles
Cells in a biofilm are thought to split into groups with different metabolism, and the lab investigates this in E. coli using both biochemistry and imaging.
*Illustrative imageGene expression in colonies and biofilms
The lab investigates the factors that affect gene expression in bacterial colonies and biofilms, as well as the role of E. coli metabolism and the characteristics of bioelectrical signals.
*Illustrative imageOmics analysis of E. coli
The lab examines the properties of E. coli cells through large-scale integrated omics analysis. It also works on discovering new enzymes and developing methods for data analysis.
MembersFaculty
- Program-Specific Associate ProfessorROBERT Martin
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lactose fermenting colonies of Escherichia coli” Ajay Kumar Chaurasiya / CC0 (cropped)
- Biofilm development and division of roles: “Mixed bacterial biofilm of staphylococci and bacilli 2” SandraG89 / CC BY-SA 4.0 (cropped)
- Gene expression in colonies and biofilms: “Gram positive and negative bacterial colony morphology on blood agar” Ajay Kumar Chaurasiya / CC BY 4.0 (cropped)
- Omics analysis of E. coli: “E coli at 10000x” Photo by Eric Erbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. / Public domain (cropped)
- Related lab (Tissue Formation Dynamics Lab): “Drosophila suzukii” Katja Schulz / CC BY 4.0 (cropped)
- Related lab (Kyoto University Ogata Lab (Microbial Ecology, Evolution, and Bioinformatics)): “Cryoelectron microscopy of the Giant Mimivirus - journal.pbio.1000092.g005” Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, et al. (2009) / CC BY 2.5 (cropped)
- Related lab (Pharmaceutical Design Lab): “Nanocapsule” GirlBossBME23 / CC BY-SA 4.0 (cropped)
- Related lab (Organic Chemistry for Drug Discovery Lab): “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
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