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Systems Chemotherapy and Molecular Regulation Lab
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A lab that finds potent bioactive molecules from microorganisms and herbal medicines to uncover how cells decide between life, death, and differentiation.
AboutAbout the lab
Sharply acting molecules that open up new science
The "life, death, and differentiation" of cells is tightly controlled by factors that determine proliferation, differentiation, and cell death. Disruption of this regulation is thought to lead to diseases such as cancer, infectious diseases, heart disease, neurodegenerative diseases, immune disorders, and diabetes.
Centered on natural products chemistry and medicinal chemistry, the lab pioneers new bioactive small molecules and uses them to carry out chemical biology research that uncovers how the "life, death, and differentiation" of cells is regulated.
Several new bioactive molecules based on the lab's research results are already sold commercially as biochemical reagents.
Key terms
- Chemical biology
- Research that uses chemical compounds as tools to investigate how life works.
- Natural products chemistry
- The study of searching for compounds made by microorganisms, plants, and other organisms, and examining their structures and functions.
- Medicinal chemistry
- Chemistry that designs and synthesizes compounds that can become drugs and improves their efficacy and properties.
- Biosynthesis
- The making of compounds by living organisms inside their bodies using enzymes.
ResearchResearch themes
The lab's research centers on three groups: chemical biology, natural products chemistry, and medicinal chemistry.
*Illustrative imageChemical biology for next-generation chemotherapy
The lab conducts chemical biology and medicinal chemistry research aimed at developing next-generation chemotherapy for multifactorial diseases such as cancer, infectious diseases, heart disease, diabetes, neurodegenerative diseases, and autoimmune diseases.
*Illustrative imageSearching natural products for new bioactive substances
From a wide range of sources, including microbial metabolites, components of herbal medicines and medicinal plants, functional foods, marine natural products, and synthetic compounds, the lab searches for small and medium-sized molecules with distinctive activity that could lead to drugs for preventing and treating disease, and develops lead compounds for drug discovery.
*Illustrative imageQuickly finding ligands and receptors
Using methods such as pathway analysis, the lab develops systems that rapidly identify pairings of small molecules and receptors based on organic chemistry, as well as highly sensitive labeling agents.
*Illustrative imageUseful substances made with genetic engineering
The lab studies the biosynthesis of natural organic compounds with distinctive structures and bioactivities, and uses molecular probes and groups of secondary metabolism enzymes to create new compounds through biosynthesis.
MembersFaculty
- ProfessorHideaki Kakeya
- Associate ProfessorAkira Hattori
- Assistant ProfessorHiroaki Ikeda
- Program-Specific Associate ProfessorShinji Kishimoto
- Program-Specific Assistant ProfessorYoshihiro Ataka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ecological Trail Garden of Medicinal and Aromatic Plants and South China Medicinal Plants Garden )” LN9267 / CC BY-SA 4.0 (cropped)
- Chemical biology for next-generation chemotherapy: “Streptomyces netropsis, formerly Streptomyces kentuckensis NRRL ISP-5052” Agricultural Research Service (NRRL)Culture Collection / Public domain (cropped)
- Searching natural products for new bioactive substances: “Maou” Hanabishi / CC BY-SA 3.0 (cropped)
- Quickly finding ligands and receptors: “IFNAR Ligand Binding” Teeny320 / CC BY-SA 4.0 (cropped)
- Useful substances made with genetic engineering: “BTEC Bioreactors” RickLawless (talk) (Uploads) / CC BY 3.0 (cropped)
- Related lab (Pathophysiological Function Analysis Lab): “Berkeley 60-inch cyclotron” Department of Energy. Office of Public Affairs / Public domain (cropped)
- Related lab (Systems Biology Lab): “Circadian rhythm labeled” National Institute of General Medical Sciences / Public domain (cropped)
- Related lab (Life Science Knowledge Engineering Lab): “Hist1 Biological Network Graph” LuAtOU / CC0 (cropped)
- Related lab (Organic Chemistry for Drug Discovery Lab): “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
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