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Tissue Formation Dynamics Lab
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A lab that studies how groups of cells move and build tissues inside the body of a living fruit fly.
AboutAbout the lab
Understanding how cells behave to build tissues
The Tissue Formation Dynamics Lab (Kuranaga Lab) was launched in April 2023 in the Graduate School of Pharmaceutical Sciences.
In the development of multicellular organisms, the body takes shape as many cells go through events such as proliferation, differentiation, adhesion, migration, and death. Programmed cell death has been found to do more than remove unneeded cells: it also helps regulate the proliferation and migration of surrounding cells.
The lab investigates how these cell behaviors are coordinated to form tissues, by capturing events as they happen in real time inside living organisms.
Key terms
- Live imaging
- A method of capturing, as video, events taking place inside living cells or organisms as they happen
- Programmed cell death
- Cell death that occurs through a defined mechanism for building and maintaining the body
- Optogenetics
- A technique that uses light to switch the activity of cells or proteins on and off
- PDX model
- A cancer research model in which a patient's tumor tissue is transplanted into an animal and grown (patient-derived xenograft)
ResearchResearch themes
In addition to the mechanisms of collective cell migration, the lab works on how to apply and measure force on tissues using optogenetics, mitochondrial dynamics in disease and aging models, and a system for evaluating drug efficacy using a new PDX model.
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MembersFaculty
- ProfessorErina Kuranaga
- ProfessorShin Yonehara
- Associate ProfessorHiroyuki Uechi
- Assistant ProfessorKomaki Ninomiya
- Assistant ProfessorMika Toya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Drosophila suzukii” Katja Schulz / CC BY 4.0 (cropped)
- Mechanisms of collective cell migration in tissue formation: “Spectrum of collective cell migration” Linus J. Schumacher, Paul M. Kulesa, Rebecca McLennan, Ruth E. Baker and Philip K. Maini / CC BY-SA 4.0 (cropped)
- Related lab (Organelle Informatics Lab): “Damaged Mitochondria (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Systems Microbiology Lab): “Lactose fermenting colonies of Escherichia coli” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Biomolecular Measurement Lab): “Mass spectrometer quadrupole” Fulvio314 / CC BY-SA 3.0 (cropped)
- Related lab (Mathematical Therapeutics Lab): “Iodine pills” Mx. Granger / CC0 (cropped)
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