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Cancer and Stem Cell Signaling Lab
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A lab that investigates how stem cells decide whether to proliferate or differentiate, in both normal tissues and cancer.
AboutAbout the lab
How is the fate of a stem cell decided?
The Cancer and Stem Cell Signaling Lab (Laboratory of Stem Cell Metabolic Regulation, Institute for Life and Medical Sciences) aims to clarify the mechanisms that determine stem cell fate.
Stem cells are capable of self-renewal, proliferating while retaining pluripotency, and they maintain tissues by supplying new cells. Cancer tissues also contain self-renewing "cancer stem cells," which are involved in therapy resistance, metastasis, and recurrence, making them an effective therapeutic target.
The lab aims to contribute to developing safe and effective treatment strategies for tissue regeneration, frailty, and cancer.
Key terms
- Stem cell
- A cell that can divide to produce copies of itself while also being able to become other types of cells
- Cancer stem cell
- A cell within cancer tissue that has self-renewal capacity and serves as the origin of the cancer
- Hematopoiesis
- The production of blood cells in the bone marrow and other sites
- RNA-binding protein
- A protein that binds to RNA and regulates its function and lifespan
ResearchResearch themes
The lab studies the mechanisms that control stem cell fate in normal tissues and in cancer, with a focus on metabolism and RNA-binding proteins.
*Illustrative imageStem cell systems in hematopoiesis and skeletal muscle
When a stem cell divides, it is determined whether the stem cell population expands or the cell differentiates into a specific cell type. Focusing on metabolism and RNA-binding proteins, the lab seeks to uncover the principles by which stem cell systems operate in hematopoietic and skeletal muscle tissues.
*Illustrative imageCancer metabolism and cell fate
The lab investigates how the breakdown of the mechanisms that determine cell fate gives rise to cancer and drives its progression. It pays particular attention to metabolism and cell fate in cancers such as myeloid leukemia.
MembersFaculty
- Associate ProfessorAyuna Hattori
- Assistant ProfessorKenkyo Matsuura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Illustration of stem cell control by the niche.” Secker, G.A., and Daniels, J.T., Limbal epithelial stem cells of the cornea (June 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.48.1, http://www.stembook.org. / CC BY 3.0 (cropped)
- Stem cell systems in hematopoiesis and skeletal muscle: “Hematopoiesis (human) diagram en” Original: A. Rad Vector: RexxS, Mikael Häggström and birdy and Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D. / CC BY-SA 3.0 (cropped)
- Cancer metabolism and cell fate: “Chronic lymphocytic leukemia” Mary Ann Thompson (VashiDonsk at en.wikipedia) / CC BY-SA 3.0 (cropped)
- Related lab (ケミカルバイオロジー): “Chemical biology flowchart” Bread6 / CC0 (cropped)
- Related lab (病因免疫学): “T Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (システムバイオロジー): “Circadian rhythm labeled” National Institute of General Medical Sciences / Public domain (cropped)
- Related lab (生体機能化学): “Zinc finger rendered” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
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