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Systems Biology Lab
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A lab that aims to develop drugs that cure disease by adjusting the timing of the circadian clock.
AboutAbout the lab
Controlling time to cure disease
Disease symptoms and the effects of drugs change periodically depending on the time of day set by the body clock. It is also known that when the circadian clock's function declines because of an irregular lifestyle or aging, a variety of diseases can occur.
The lab aims to establish time-based pharmaceutical science grounded in biological rhythms.
Creating drugs based on the new idea of adjusting the timing of the body clock could fundamentally improve diseases caused by circadian clock abnormalities.
Key terms
- Circadian clock
- The mechanism inside the body that keeps a rhythm of about 24 hours.
- Circadian rhythm
- A rhythm of bodily functions that repeats on a cycle of about 24 hours.
- G protein-coupled receptor
- A receptor in the cell membrane that relays signals from outside into the cell. It is the target of many drugs.
- Aldosteronism
- A disease in which too much aldosterone, a hormone that raises blood pressure, is released, causing hypertension and other problems.
ResearchResearch themes
The lab aims to establish time-based treatment ("Time Medicine") for lifestyle-related diseases such as insomnia and hypertension, and for age-related diseases.
*Illustrative imageDrugs that tune the central circadian clock
The lab discovered Gpr176, a G protein-coupled receptor that regulates the central circadian clock. Through comprehensive searches of compound libraries, it aims to develop drugs that adjust biological rhythms.
*Illustrative imageTime-based treatment of age-related disease
The lab studies how the brain's central circadian rhythm and the clocks in the body's organs are involved in age-related organ dysfunction. By developing anti-aging and health-maintenance methods that make use of the circadian clock, it seeks to get at the essence of how aging works.
*Illustrative imageMorning types, evening types, and body temperature during naps
The lab discovered RGS16, a protein involved in waking up, as a gene that determines whether a person is a "morning type," and this was also confirmed in a large-scale human cohort study.
*Illustrative imageAbnormal biological rhythms and hypertension
The lab has clarified the mechanism by which circadian clock abnormalities cause hypertension. It is pursuing clinical application research to use a causative molecule of hypertension, found in mice with abnormal biological rhythms, in the treatment of aldosteronism in humans.
MembersFaculty
- ProfessorMasao Doi
- Associate ProfessorEmi Hasegawa
- LecturerMACPHERSON Tom
- Assistant ProfessorHSIAO Sui-Wen
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Circadian rhythm labeled” National Institute of General Medical Sciences / Public domain (cropped)
- Drugs that tune the central circadian clock: “Suprachiasmatic nucleus is the central circadian pacemaker” Robin M. Voigt, Ph.D., Christopher B. Forsyth, Ph.D., and Ali Keshavarzian, M.D. / Public domain (cropped)
- Time-based treatment of age-related disease: “Sleeping-girl” rachel CALAMUSA at the Wayback Machine / CC BY-SA 2.0 (cropped)
- Morning types, evening types, and body temperature during naps: “Morning setting with a banana, vintage clock, and smartphone on a table during bright daylight” Shixart1985 / CC BY 2.0 (cropped)
- Abnormal biological rhythms and hypertension: “Blood pressure measurement (1)” Víctor Santa María from Buenos Aires, Argentina / CC BY 2.0 (cropped)
- Related lab (Organic Chemistry for Drug Discovery Lab): “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacogenomics and Genomic Drug Discovery Lab): “Rasyslami” The original uploader was (Automated conversion) at English Wikipedia. / CC BY-SA 3.0 (cropped)
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- Related lab (Pathophysiological Function Analysis Lab): “Berkeley 60-inch cyclotron” Department of Energy. Office of Public Affairs / Public domain (cropped)
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