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Organic Chemistry for Drug Discovery Lab
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A lab that creates drugs from organic chemistry, using hard-to-synthesize molecules and new reactions.
AboutAbout the lab
Opening paths to new drugs, built on organic chemistry
Most biomolecules and drugs are organic compounds, so a deep understanding of organic chemistry is essential for making drugs and using them correctly.
Good drugs have already been developed for diseases that are easy to treat, leaving the diseases that are hard to treat. If compounds that are difficult to synthesize can be used in drug discovery, or if interactions between biomolecules that have been hard to regulate can be controlled, they could open the way to new drugs.
The lab aims at drug discovery grounded in organic chemistry.
Key terms
- Alkaloid
- A nitrogen-containing natural organic compound made by plants and other organisms. Many have strong biological activity.
- Transition metal catalyst
- A catalyst that uses metals such as gold and palladium to drive chemical reactions.
- Antibody therapeutics
- A drug that makes use of the mechanism of antibodies produced by the body's immune system.
- Compound library
- A large collection of compounds gathered to search for drug candidates.
ResearchResearch themes
The lab works on four areas: synthesis of natural products that are difficult to make, development of new reactions, antibody modification technologies, and use of compound libraries.
*Illustrative imageSynthesis of bioactive compounds and their development into drugs
The lab synthesizes natural organic compounds with structures that are difficult to make and develops them into drug candidates, working on alkaloids with complex ring structures and macrocyclic peptides.
*Illustrative imageReactions that assemble complex structures in one step
The lab develops methods to efficiently build, in a single reaction, the complex structures common to bioactive compounds. Focusing on atom-economical reactions, it develops reactions that use transition metal catalysts such as gold and palladium.
*Illustrative imageEnhancing antibody therapeutic candidates
Combining biochemical methods from protein engineering with conjugation chemistry based on organic chemistry, the lab is creating new antibody modification technologies.
Searching a compound library for functional molecules
The lab has compiled tens of thousands of compounds it has synthesized over many years, including natural organic compounds such as alkaloids and peptide hormones, into a compound library, and carries out a variety of screenings in collaboration with researchers inside and outside the university.
MembersFaculty
- ProfessorHiroaki Ohno
- LecturerHiroki Akiba
- Assistant ProfessorNorihito Arichi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chemical structure of necine bases” Xu, J., Wang, W., Yang, X., Xiong, A., Yang, L., & Wang, Z. / CC BY-SA 4.0 (cropped)
- Synthesis of bioactive compounds and their development into drugs: “Apparatus for nitration of organic substances - DPLA - 458f19d0057e a9cc18c2cf8” 作者不詳 / Public domain (cropped)
- Reactions that assemble complex structures in one step: “Organic Chemistry Lab 5 by marthou” Marthou / CC BY-SA 4.0 (cropped)
- Enhancing antibody therapeutic candidates: “Antibody-drug-conjugate 01” User:Kuebi = Armin Kübelbeck / CC BY-SA 3.0 (cropped)
- Related lab (Pharmaceutical Synthetic Chemistry Lab): “Verrerie-p1030896” Rama / CC BY-SA 2.0 fr (cropped)
- Related lab (Systems Biology Lab): “Circadian rhythm labeled” National Institute of General Medical Sciences / Public domain (cropped)
- Related lab (Systems Chemotherapy and Molecular Regulation Lab): “Ecological Trail Garden of Medicinal and Aromatic Plants and South China Medicinal Plants Garden )” LN9267 / CC BY-SA 4.0 (cropped)
- Related lab (Chemical Biology Lab): “Chemical biology flowchart” Bread6 / CC0 (cropped)
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