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Biomolecular Measurement Lab
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The lab develops technology to measure all the proteins inside cells at once, in order to understand how cells work and to advance drug discovery.
AboutAbout the lab
Measuring every protein.
The Biomolecular Measurement field (Ishihama Lab) is built around analytical science and aims to uncover the functions of cells and molecules by measuring the molecules that make up living organisms.
Using mass spectrometry, trace-level separation analysis, computational science, cell biology, and other approaches, the lab develops methodologies for proteome analysis and applies them to analyzing cell function and to drug development.
For each field opened up by new technology, the lab aims to follow through to its biological applications.
Key terms
- Proteome
- The entire set of proteins in a cell or tissue
- Mass spectrometry
- A method that measures the mass of molecules precisely to determine which substances are present and in what amounts
- Phosphorylation
- The attachment of a phosphate tag to a protein. It switches signals inside the cell on and off
- Molecularly targeted drug
- A drug that acts only on a specific molecule involved in a disease
ResearchResearch themes
Measurement technology is still a bottleneck in proteome research, and it remains impossible to measure all the proteins working inside cells at once. The lab tackles this measurement challenge.
*Illustrative imageNew technology to measure all proteins at once
The lab is developing a system that uses meter-long columns with ultra-high separation power made in the lab to separate complex samples while measuring them with a mass spectrometer, and then analyzes the data with its own data processing methods.
*Illustrative imagePhosphorylation networks inside cells
The lab developed its own method for enriching phosphopeptides, and it has become clear that more than 70% of human proteins undergo phosphorylation.
*Illustrative imageApplications in drug discovery and clinical medicine
The lab uses the phosphoproteomics system it developed as a tool to support drug discovery by investigating how molecularly targeted cancer drugs act.
MembersFaculty
- ProfessorYasushi Ishihama
- Assistant ProfessorKosuke Ogata
- Assistant ProfessorEisuke Kanao
- Program-Specific Assistant ProfessorHiroshi Nishida
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mass spectrometer quadrupole” Fulvio314 / CC BY-SA 3.0 (cropped)
- New technology to measure all proteins at once: “Hplc kolom jsw” Imgupl / Public domain (cropped)
- Phosphorylation networks inside cells: “MPF” Moon rabbit 365 / CC BY-SA 4.0 (cropped)
- Applications in drug discovery and clinical medicine: “HK Chai Wan IVE Pharmaceutical Science Laboratory Codonopsis pilosula Room 516” Chlaborewan / CC BY-SA 3.0 (cropped)
- Related lab (Life Science Knowledge Engineering Lab): “Hist1 Biological Network Graph” LuAtOU / CC0 (cropped)
- Related lab (Pharmaceutical Functional Analysis Lab): “Liquid chromatograph with mass spectrometer in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Related lab (Tissue Formation Dynamics Lab): “Drosophila suzukii” Katja Schulz / CC BY 4.0 (cropped)
- Related lab (Mathematical Therapeutics Lab): “Iodine pills” Mx. Granger / CC0 (cropped)
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