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100 labs · 10 student voices
Faculties at Kyoto University ›
FAGARASAN Sidonia, Professor
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The lab studies how immune function coordinates with the body's other systems. Through research on mucosal immunity in the gut, the lab has clarified the regulation of symbiotic bacteria and the mucosal barrier, as well as the role gut immunity plays in maintaining homeostasis. More recently, the lab has also found that long-lasting immune responses throughout the body can affect brain function and cause changes in emotion. Using cutting-edge multiomics technologies, the lab aims to develop new therapies for immune-related diseases.
Kenji Chamoto, Professor
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The lab aims to comprehensively understand, at the molecular, cellular, and metabolic levels, how the immune response against cancer is regulated, and to create the next generation of cancer immunotherapy. Immune checkpoint blockade therapy does not work sufficiently in more than half of patients, and clarifying why it fails to work, or stops working partway through treatment, is a major challenge. Focusing on the metabolism of immune cells, especially mitochondrial function, the lab explores the mechanisms of immune regulation across cancer, aging, and inflammation. As a division of the Center for Cancer Immunotherapy and Immunobiology, the lab moves back and forth between basic and clinical research.
Hirotake Tsukamoto, Program-Specific Associate Professor
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The lab studies why cancer immunotherapy does not work in some patients, and the mechanisms behind reactions in which treatment causes the body to attack itself. In cancer immunotherapy such as anti-PD-(L)1 therapy, immune-related adverse events (irAEs) can damage organs, and treatment sometimes has to be discontinued. The lab explores ways to resolve a contradictory challenge: suppressing side effects too much reduces efficacy, while strengthening efficacy increases the risk of attacking one's own body. The lab is a division of the Center for Cancer Immunotherapy and Immunobiology and collaborates with the clinical departments of Kyoto University Hospital.
Ken Takahashi, Associate Professor
0 student voices
The lab uses the power of innate immunity to pursue the clinical development of a new cancer immunotherapy that enhances the effect of PD-1 blockade therapy. Drawing on experience in treating digestive diseases and in research on immunity against cancer and viruses centered on innate immunity, the lab aims to bring the results of basic research back to actual clinical care. The lab is a division of the Center for Cancer Immunotherapy and Immunobiology, established in April 2023.
Yukiko Mori, Professor
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The lab is a division of the Medical DX Education and Research Center, affiliated with the Graduate School of Medicine, and its mission is "building a role model for a medical data utilization infrastructure in Japan." Beyond providing facilities, the lab expands horizontal connections among people across the university, aiming to create a place where high-quality research on par with the world's best can emerge. Its work rests on three pillars: advanced use of external data and support for industry-academia collaboration; open science and research data management; and operating an infrastructure for uses that benefit the health and interests of the public. The lab promotes interdisciplinary research that goes beyond medicine, and trains medical information professionals with strong foundational skills, applied skills, and communication skills.
Akifumi Takaori, Professor
0 student voices
Hematology is a field in which clinical and basic research are closely linked, and the lab applies the results of basic research to elucidating disease mechanisms, diagnosis, and the development of treatments. Under the motto "From bedside to bench. From bench to bedside." the lab devotes itself to clinical care, research, and education, aiming to cure intractable blood diseases. With cures for blood cancers and infectious diseases as its main themes, the lab conducts research from both clinical and basic angles. Some of its labs work on leukemia, tumor immunology, transplant immunology, HIV, and iPS cells. The lab welcomes not only those who aim to become researchers but also those who aim to become clinicians and want to deepen their knowledge through basic research.
Koh Ono, Professor
0 student voices
Cardiovascular medicine deals with diseases such as angina, myocardial infarction, valvular heart disease, heart failure, atherosclerosis, aneurysms, and arrhythmias. In its research, the lab draws on basic and clinical approaches in balance, aiming to create new value from Kyoto for the world. In basic research, the lab uses new methods that apply molecular biology, physiology, and genetics to answer questions that arise in clinical practice. In clinical research, it carries out large-scale multicenter trials in cooperation with many affiliated hospitals. The lab also welcomes early-career researchers and people from other fields.
Hiroshi Seno, Professor
0 student voices
Gastroenterology research at the lab covers a wide range of digestive diseases, from the esophagus, stomach, and intestines to the liver, bile ducts, and pancreas. The lab's starting points are questions that arise in clinical practice, such as why diseases occur, and why their progression and response to treatment differ from person to person. The lab seeks to understand how a disease begins and how it changes over time, at many levels from molecules, cells, and tissues to groups of patients. The lab aims to train "bilingual" professionals who are clinicians and also understand basic medical science.
Toyohiro Hirai, Professor
0 student voices
The lab studies a wide range of respiratory diseases, including cancer, infections, COPD (chronic obstructive pulmonary disease), asthma, interstitial lung disease, sleep-disordered breathing, and respiratory failure. The lung is an organ that performs gas exchange at the interface of air and blood and keeps changing shape with each breath, and its diseases can overlap with one another or be linked to diseases of other organs. The lab aims to bring together knowledge from many fields, not only medicine and biology but also science and engineering, to build a new framework of respiratory medicine. The lab also conducts clinical research using clinical information from many institutions, including affiliated facilities, and collaborative research with basic medicine departments and other faculties.
Akio Morinobu, Professor
0 student voices
Clinical Immunology is a department that treats immune diseases such as rheumatic and connective tissue diseases, and a field that serves as a bridge between basic immunology and clinical medicine. Patients with rheumatic and connective tissue diseases are treated using cutting-edge immunological therapies. At the same time, the mechanisms of autoimmunity are still not fully understood, and many new challenges remain, such as autoimmune diseases that appear as a side effect of cancer immunotherapy. The lab aims to resolve the challenges of clinical immunology using methods from immunology, life sciences, and information science, and to bring the results back to clinical practice.
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