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Higher-Order Inter-System Regulation Lab
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The lab explores how the immune system connects with metabolism and the brain to keep the body in balance.
AboutAbout the lab
The immune system is connected to the whole body.
The lab studies how immune function coordinates with the body's other systems.
Through research on mucosal immunity in the gut, the lab has clarified the regulation of symbiotic bacteria and the mucosal barrier, as well as the role gut immunity plays in maintaining homeostasis.
More recently, the lab has also found that long-lasting immune responses throughout the body can affect brain function and cause changes in emotion.
Using cutting-edge multiomics technologies, the lab aims to develop new therapies for immune-related diseases.
Key terms
- Homeostasis
- The tendency of the body to keep its state stable even when the environment outside or inside the body changes
- Metabolites
- Small molecules produced in the processes by which substances are made and broken down in the body
- Multiomics
- An approach that comprehensively examines molecules in the body, such as genes, proteins, and metabolites, across multiple layers
ResearchResearch themes
The immune system produces optimal responses and supports homeostasis through coordination between signals from outside cells and metabolic pathways inside cells. The lab aims to clarify in detail how the immune system receives signals such as metabolites and neurotransmitters and how it produces responses, and to connect this to new therapies for immune-related diseases.
*Illustrative imageMetabolism during immune cell activation
The lab analyzes how metabolism inside cells changes when innate and adaptive immune cells are activated.
*Illustrative imageImmune regulation by metabolites
The lab aims to uncover how immune cells influence one another through metabolites and how immune responses are regulated. It is also working to develop new therapies for cancer and autoimmune diseases that target metabolic pathways.
*Illustrative imageConnections between immunity, gut bacteria, and the brain
The lab investigates interactions between the immune system and gut bacteria and other systems of the body. It aims to understand how immune cells affect gut bacteria, the brain, and the endocrine system when homeostasis is maintained and when it is disrupted.
MembersFaculty
- ProfessorFAGARASAN Sidonia
- Associate ProfessorBaihao Zhang
- LecturerMasaki Tajima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
- Metabolism during immune cell activation: “Mitochondria 5 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Immune regulation by metabolites: “Mitochondria 7 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Connections between immunity, gut bacteria, and the brain: “Liu gut-brain-axis schema” Eldeane / CC BY-SA 4.0 (cropped)
- Related lab (免疫細胞生物学): “Follicular helper T (Tfh) and T follicular regulatory (Tfr) cells both act in the germinal center (GC) to regulate the generation of antigen (Ag)-specific antibody-secreting cells” Xie MM and Dent AL / CC BY 4.0 (cropped)
- Related lab (がん免疫多細胞システム制御): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (免疫薬理学): “Prostaglandin F2alpha 3d” Иван / Public domain (cropped)
- Related lab (医化学): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
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