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Clinical Immunology Lab
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The lab investigates the mechanisms of autoimmune diseases such as rheumatic and connective tissue diseases and brings its findings back to clinical care.
AboutAbout the lab
A bridge between basic immunology and clinical medicine.
Clinical Immunology is a department that treats immune diseases such as rheumatic and connective tissue diseases, and a field that serves as a bridge between basic immunology and clinical medicine.
Patients with rheumatic and connective tissue diseases are treated using cutting-edge immunological therapies.
At the same time, the mechanisms of autoimmunity are still not fully understood, and many new challenges remain, such as autoimmune diseases that appear as a side effect of cancer immunotherapy.
The lab aims to resolve the challenges of clinical immunology using methods from immunology, life sciences, and information science, and to bring the results back to clinical practice.
Key terms
- Autoimmune disease
- A disease in which the immune system mistakenly attacks the body's own tissues
- Autoantibody
- An antibody that attacks the body's own components
- Genome-wide association study
- A study that compares the whole genomes of many people to find genetic locations associated with susceptibility to a disease
ResearchResearch themes
The lab studies the causes and pathogenesis of autoimmune diseases, connective tissue diseases, and rheumatic diseases in order to develop new diagnostic methods and treatments.
*Illustrative imageGenetic Studies of Takayasu Arteritis
In a genome-wide association study using blood samples from 633 patients with Takayasu arteritis, the lab identified new genetic loci associated with the disease. The analysis suggests that NK cells are involved in its pathology.
*Illustrative imageAutoantibodies in Connective Tissue Diseases and Interstitial Pneumonia
The lab searches for autoantibodies associated with connective tissue diseases and interstitial pneumonia, together with their targets, and has identified several. For intractable conditions, it has also conducted a clinical study of treatment that strongly suppresses the immune system.
*Illustrative imageLipid Mediators and Rheumatoid Arthritis
Using blood and adipose tissue, the lab analyzes how anti-inflammatory lipid mediators, their receptors, and their signaling affect the pathology of rheumatoid arthritis.
*Illustrative imageA Gene That Maintains Immune Tolerance
The lab identified phospholipase D4 as a gene associated with susceptibility to rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, and reported its role in maintaining immune tolerance in B cells.
MembersFaculty
- ProfessorAkio Morinobu
- Associate ProfessorHajime Yoshifuji
- LecturerRan Nakashima
- Assistant ProfessorShuji Akizuki
- Assistant ProfessorHideaki Tsuji
- Assistant ProfessorRyosuke Hiwa
- Program-Specific Hospital Assistant ProfessorMirei Shirakashi
- Program-Specific Hospital Assistant ProfessorTsuneo Nakashima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rheumatoid arthritis -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Genetic Studies of Takayasu Arteritis: “Aorta Anatomy-zh” User:Lukesanatomy / CC BY-SA 3.0 (cropped)
- Autoantibodies in Connective Tissue Diseases and Interstitial Pneumonia: “Antibody (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Lipid Mediators and Rheumatoid Arthritis: “Adipocytes Lipid Droplets Oil Red O Staining Rkott 2023” Rkott / CC BY-SA 4.0 (cropped)
- A Gene That Maintains Immune Tolerance: “Chromosome-DNA-gene copy” Thomas Splettstoesser / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Immunotherapy Lab): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Neurosurgery Lab): “MRA Moya-moya-disease” commons:User:MBq, commons:User:SBarnes / CC BY-SA 3.0 (cropped)
- Related lab (Biological Information Science Lab): “STAT Optogenetics MIT Handout” statenews website hayadan website / CC BY 2.5 (cropped)
- Related lab (Oral Surgery Lab): “Dental Implant Key Terms” 95Berlin / CC BY-SA 2.5 (cropped)
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