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Cancer Immunotherapy and Clinical Immunology Lab
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The lab seeks to optimize the balance between the efficacy and side effects of cancer immunotherapy.
AboutAbout the lab
Toward cancer immunotherapy that achieves both efficacy and safety
The lab studies why cancer immunotherapy does not work in some patients, and the mechanisms behind reactions in which treatment causes the body to attack itself.
In cancer immunotherapy such as anti-PD-(L)1 therapy, immune-related adverse events (irAEs) can damage organs, and treatment sometimes has to be discontinued.
The lab explores ways to resolve a contradictory challenge: suppressing side effects too much reduces efficacy, while strengthening efficacy increases the risk of attacking one's own body.
The lab is a division of the Center for Cancer Immunotherapy and Immunobiology and collaborates with the clinical departments of Kyoto University Hospital.
Key terms
- Immune-related adverse events
- Side effects in which cancer immunotherapy strengthens the immune system so much that it attacks the patient's own organs
- Anti-PD-(L)1 therapy
- Treatment that uses antibodies to block the function of PD-1 and PD-L1, molecules that act as brakes on the immune system, thereby strengthening the attack on cancer
- Combination cancer immunotherapy
- Cancer immunotherapy that combines several treatments
ResearchResearch themes
The lab studies the factors that determine the safety and efficacy of treatment, based on changes in immune cell activity caused by cancer immunotherapy and on the immune characteristics of older adults, who make up much of the cancer patient population.
*Illustrative imageMechanisms of immune-related adverse events and combination cancer immunotherapy
The lab clarifies the factors involved in immune-related adverse events and their molecular mechanisms. It aims to lay the foundation for combination cancer immunotherapy that achieves both efficacy against cancer and suppression of side effects, and to apply it in the clinic.
*Illustrative imageResearch on adverse events in collaboration with the hospital
In 2021, the lab launched the “irAE Unit” within Kyoto University Hospital, supporting the care of cancer patients. It also works to identify the causes of adverse events by immunologically analyzing clinical information and specimens such as blood.
MembersFaculty
- Program-Specific Associate ProfessorHirotake Tsukamoto
- Program-Specific Associate ProfessorKosaku Murakami
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PD-1, PD-L1 and CTLA-4 targets of immune checkpoint inhibitors” Alexandre Perrier, Audrey Didelot, Pierre Laurent-Puig, Hélène Blons and Simon Garinet / CC BY 4.0 (cropped)
- Mechanisms of immune-related adverse events and combination cancer immunotherapy: “Mechanism of action of PD-1-PD-L1 inhibitors” Feng Li1,Binchi Liao,Ting Wang,Tingting Qi,Yixin Wang / CC BY 4.0 (cropped)
- Research on adverse events in collaboration with the hospital: “Kyoto-u” Ayumi2000 / CC BY 3.0 (cropped)
- Related lab (Immune Cell Biology Lab): “Follicular helper T (Tfh) and T follicular regulatory (Tfr) cells both act in the germinal center (GC) to regulate the generation of antigen (Ag)-specific antibody-secreting cells” Xie MM and Dent AL / CC BY 4.0 (cropped)
- Related lab (Cancer Immunotherapy Lab): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Molecular and Cellular Physiology Lab): “Taste bud esp” NEUROtiker / CC BY-SA 3.0 (cropped)
- Related lab (Cancer Immune Response Regulation Lab): “Mitochondria 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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