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Gastroenterology Lab
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A lab that starts from clinical questions to uncover how digestive diseases begin and progress.

AboutAbout the lab
Asking questions from the clinic, and returning answers to patient care.
Gastroenterology research at the lab covers a wide range of digestive diseases, from the esophagus, stomach, and intestines to the liver, bile ducts, and pancreas.
The lab's starting points are questions that arise in clinical practice, such as why diseases occur, and why their progression and response to treatment differ from person to person.
The lab seeks to understand how a disease begins and how it changes over time, at many levels from molecules, cells, and tissues to groups of patients.
The lab aims to train "bilingual" professionals who are clinicians and also understand basic medical science.
Key terms
- Organoid
- A small three-dimensional tissue that resembles an organ, grown in a test tube from stem cells or similar cells
- Autoantibody
- An antibody that mistakenly attacks the body's own components
- MicroRNA
- A small RNA that regulates the activity of genes. It also circulates in the blood and can serve as a clue to disease
ResearchResearch themes
By combining patients' clinical specimens, organoids, genetically modified mice, genome analysis, single-cell analysis, and real-world data, the lab aims to deepen the understanding of disease and to conduct research that leads to earlier diagnosis, more appropriate treatment, and future prevention.
*Illustrative imageRecreating the Natural History of Digestive Cancers
Using patient-derived organoids and genetically modified mice, the lab recreates the process from normal tissue to precancerous lesions, early cancer, advanced cancer, and metastasis.
*Illustrative imageLiver Diseases, from Cause to Treatment
The lab studies how liver diseases arise and progress, including hepatitis B and C, fatty liver disease (MASLD/MASH), cirrhosis, and liver cancer.
*Illustrative imageUnderstanding Digestive Diseases through Inflammation and Immunity
Using autoantibodies found in patients with ulcerative colitis as a clue, the lab is working on diagnosis, prediction of treatment response, and applications to diseases such as primary sclerosing cholangitis.
*Illustrative imageFinding Disease Early and Accurately from Blood
The lab comprehensively analyzes microRNAs in the blood and combines the results with machine learning to study diagnostic methods that detect pancreatic cancer from a blood sample. How to detect early-stage pancreatic cancer in particular is a major challenge for the lab.
MembersFaculty
- ProfessorHiroshi Seno
- Associate ProfessorAkihisa Fukuda
- Assistant ProfessorShuji Yamamoto
- Assistant ProfessorAtsushi Takai
- Assistant ProfessorMasahiro Shiokawa
- Assistant ProfessorYuki Nakanishi
- Assistant ProfessorTakahiro Utsumi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CSIRO ScienceImage 11130 CSIROs colonoscopy simulator developed using the latest computer gaming technology” division, CSIRO / CC BY 3.0 (cropped)
- Recreating the Natural History of Digestive Cancers: “Organoïde intestinal” Paul Barreau / CC BY-SA 4.0 (cropped)
- Liver Diseases, from Cause to Treatment: “Liver, posterior view with labels. ( )” John Campbell / CC0 (cropped)
- Understanding Digestive Diseases through Inflammation and Immunity: “Antibody (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Finding Disease Early and Accurately from Blood: “Blood collection renal function test tube” Fumikas Sagisavas / CC0 (cropped)
- Related lab (Forensic Medicine Lab): “Institut für Rechtsmedizin der Uniklinik Köln-3222” Raimond Spekking / CC BY-SA 4.0 (cropped)
- Related lab (Cardiovascular Medicine Lab): “2D ECHOCARDIOGRAM MACHINE WITH A TABLE AND A STETHOSCOPE” Dr D. Malleswara Rao / CC BY-SA 4.0 (cropped)
- Related lab (Respiratory Medicine Lab): “Spirometry NIH” National Heart Lung and Blood Insitute (NIH) / Public domain (cropped)
- Related lab (Urology Lab): “Prostate Cancer ( )” National Human Genome Research Institute (NHGRI) from Bethesda, MD, USA / CC BY 2.0 (cropped)
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