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Hematology Lab
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A hematology lab working toward cures for blood cancers such as leukemia and for infectious diseases.
AboutAbout the lab
Aiming to cure intractable blood diseases.
Hematology is a field in which clinical and basic research are closely linked, and the lab applies the results of basic research to elucidating disease mechanisms, diagnosis, and the development of treatments.
Under the motto "From bedside to bench. From bench to bedside." the lab devotes itself to clinical care, research, and education, aiming to cure intractable blood diseases.
With cures for blood cancers and infectious diseases as its main themes, the lab conducts research from both clinical and basic angles. Some of its labs work on leukemia, tumor immunology, transplant immunology, HIV, and iPS cells.
The lab welcomes not only those who aim to become researchers but also those who aim to become clinicians and want to deepen their knowledge through basic research.
Key terms
- Adult T-cell leukemia
- A blood cancer caused by infection with a virus called HTLV-1
- Graft-versus-host disease
- A complication in which immune cells from the transplanted donor attack the patient's body (GVHD)
- CAR-T cell therapy
- A treatment in which a patient's T cells are modified to carry a receptor that recognizes cancer, then returned to the body
ResearchResearch themes
The lab conducts research that spans hematology, immunology, and infectious disease medicine, from basic to clinical: the pathology and treatment of hematologic malignancies, carcinogenesis driven by genomic mutations (APOBEC3), infectious diseases such as HIV and host defense, studies of blood diseases using iPS cells, dendritic cells and cancer immunotherapy, and hematopoietic cell transplantation and CAR-T cell therapy.
*Illustrative imagePathology of adult T-cell leukemia
Centered on adult T-cell leukemia, the lab studies blood cancers. Using comprehensive genetic analysis and models with immunodeficient mice, it aims to clarify how tumors grow and what happens in the disease clinically.
*Illustrative imageDNA repair defects in leukemia and early diagnosis
The lab is attempting to develop treatments that target abnormalities in DNA repair mechanisms in adult T-cell leukemia and the vulnerabilities that come with them.
*Illustrative imageDendritic cells and tumor immunology
Focusing on dendritic cells, the command centers of the immune system, and on the T cells and NK cells that attack tumors, the lab analyzes immune mechanisms in blood cancers.
*Illustrative imageControl of transplant immunity
Many of the challenges of hematopoietic stem cell transplantation involve immunity. The lab studies methods that use MEK inhibitors to selectively suppress graft-versus-host disease while preserving immunity against infection and the effect against tumors, and is extending this work to solid organ transplantation.
MembersFaculty
- ProfessorAkifumi Takaori
- Associate ProfessorKohei Yamashita
- LecturerJunya Kanda
- LecturerKotaro Shirakawa
- Assistant ProfessorToshio Kitawaki
- Assistant ProfessorKazuhisa Chonabayashi
- Assistant ProfessorTakashi Sakamoto
- Assistant ProfessorHiroshi Arima
- Assistant ProfessorTadahiko Matsumoto
- Assistant ProfessorChisaki Mizumoto
- Assistant ProfessorKenichi Ishiyama
- Assistant ProfessorNoriyoshi Yoshinaga
- Assistant ProfessorHiroyuki Matsui
- Assistant ProfessorYasuyuki Arai
- Assistant ProfessorTomoyasu Jo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Peripheral blood smear of acute promyelocytic leukemia, hypogranular variant, source image (6)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Pathology of adult T-cell leukemia: “HTLV-1 EM 8241 lores” 作者不詳 / Public domain (cropped)
- DNA repair defects in leukemia and early diagnosis: “Peripheral blood smear of acute promyelocytic leukemia, hypogranular variant, source image (3)” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Dendritic cells and tumor immunology: “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Control of transplant immunity: “Bone Marrow Transplant” Mugwump12 / CC BY-SA 3.0 (cropped)
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