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Cancer Immunotherapy Lab
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The lab awakens immunity locally within tumors to enhance the effect of PD-1 blockade therapy.
AboutAbout the lab
Awakening immunity right at the site of the cancer
The lab uses the power of innate immunity to pursue the clinical development of a new cancer immunotherapy that enhances the effect of PD-1 blockade therapy.
Drawing on experience in treating digestive diseases and in research on immunity against cancer and viruses centered on innate immunity, the lab aims to bring the results of basic research back to actual clinical care.
The lab is a division of the Center for Cancer Immunotherapy and Immunobiology, established in April 2023.
Key terms
- In situ vaccine
- A method that activates immunity directly at the site of the cancer so that the patient's own cancer works as a vaccine
- Innate immunity
- Immunity that is present from birth. It quickly detects foreign substances and provides the first line of defense
- Adjuvant
- A substance added to strengthen the immune response
ResearchResearch themes
Cancer immunity begins when innate immunity is activated at the site of the cancer, and dendritic cells take up the released cancer antigens and present them to T cells. Few patients respond to checkpoint inhibitors, so new immunotherapies that enhance their effect are needed.
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MembersFaculty
- Associate ProfessorKen Takahashi
- Program-Specific Assistant ProfessorMARAM Hussein Zaky
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Development of in situ vaccines: “A clinically translatable, irreversibly attenuated Salmonella strain as a next-generation adjuvant for checkpoint immunotherapy” Dinh-Huy Nguyen-1984 / CC BY 4.0 (cropped)
- Related lab (免疫薬理学): “Prostaglandin F2alpha 3d” Иван / Public domain (cropped)
- Related lab (臨床免疫学): “Rheumatoid arthritis -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (脳神経外科学): “MRA Moya-moya-disease” commons:User:MBq, commons:User:SBarnes / CC BY-SA 3.0 (cropped)
- Related lab (口腔外科学): “Dental Implant Key Terms” 95Berlin / CC BY-SA 2.5 (cropped)
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