LAB LOGA page on LabLog, a review site (not the lab's official page)
Cancer Immune Response Regulation Lab
Machine-translated · View original
The lab works to overcome the barrier that makes cancer immunotherapy ineffective by restoring the metabolism of immune cells.
AboutAbout the lab
Making immune cells healthy.
The lab aims to comprehensively understand, at the molecular, cellular, and metabolic levels, how the immune response against cancer is regulated, and to create the next generation of cancer immunotherapy.
Immune checkpoint blockade therapy does not work sufficiently in more than half of patients, and clarifying why it fails to work, or stops working partway through treatment, is a major challenge.
Focusing on the metabolism of immune cells, especially mitochondrial function, the lab explores the mechanisms of immune regulation across cancer, aging, and inflammation.
As a division of the Center for Cancer Immunotherapy and Immunobiology, the lab moves back and forth between basic and clinical research.
Key terms
- Immune checkpoint blockade therapy
- A treatment that releases the brakes on the immune system (such as PD-1) to strengthen the attack on cancer
- Mitochondria
- Small organelles inside cells that produce energy
- Translational research
- Research that bridges the results of basic research to treatment and diagnosis in hospitals
ResearchResearch themes
The lab conducts research from the perspective that the metabolic state of immune cells determines the quality and persistence of the immune response against cancer and how well treatment works. It also investigates how stresses such as hypoxia and inflammation around tumors affect T cells and macrophages, as well as changes in immunity caused by aging.
*Illustrative imageTranslational research across cancer and inflammatory environments
The lab pursues translational research that takes an interdisciplinary approach to understanding cancer and inflammatory environments at the cellular, metabolic, and molecular levels, and bridges the resulting findings to the clinic.
*Illustrative imageWhy anti-PD-1 antibodies fail to work
The lab analyzes why anti-PD-1 antibodies fail to work from perspectives such as mitochondrial function, oxidative stress, and aging. It is developing rational combination therapies that suppress the decline and exhaustion of T cell function.
MembersFaculty
- ProfessorKenji Chamoto
- Program-Specific Assistant ProfessorKoji Kitaoka
VoicesStudent voices
Ratings and reviews reflect the experiences of individual current or former students, not the lab's official views. Whether a lab has reviews, or how many, says nothing about the lab itself.
Students who take part in an interview may receive a thank-you gift worth ¥1,000, regardless of what they say.
Student ratings (0 students)
--
--
--
--
--
--
Student voices answer questions like these
- What's great about this lab?
- What did you learn after joining?
- What's the vibe, and what is the professor like?
- Who is this lab for?
- Where do graduates go?
Your experience can help younger students choose their lab. Your name won't be shown.
Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Cancer Immune Response Regulation Lab
Immune Cell Biology LabFaculty of Medicine, School of Medicine- Human immunology - The immune system is an essential mecha…
Diabetes, Endocrinology and Nutrition LabFaculty of Medicine, School of MedicineIntegrated research from pathophysiology to the creation of …
Medical Chemistry LabFaculty of Medicine, School of MedicineImmune responses are tightly regulated in the body, eliminat…
Cancer Immune Multicellular System Regulation LabFaculty of Medicine, School of MedicineTumor immunology and cancer biology: comprehensive analysis …The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mitochondria 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Translational research across cancer and inflammatory environments: “Immune checkpoint blockade of T-cell activity and mechanism of action of checkpoint inhibitors” Law, A.M.K.; Valdes-Mora, F.; Gallego-Ortega, D. / CC BY 4.0 (cropped)
- Why anti-PD-1 antibodies fail to work: “Antibody (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Immune Cell Biology Lab): “Follicular helper T (Tfh) and T follicular regulatory (Tfr) cells both act in the germinal center (GC) to regulate the generation of antigen (Ag)-specific antibody-secreting cells” Xie MM and Dent AL / CC BY 4.0 (cropped)
- Related lab (Diabetes, Endocrinology and Nutrition Lab): “Suckale08 fig2 islet structure” Jakob Suckale, Michele Solimena / CC BY 3.0 (cropped)
- Related lab (Medical Chemistry Lab): “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
- Related lab (Cancer Immune Multicellular System Regulation Lab): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
About LabLog
LabLog is a lab review app for students only. Student members at each university interview students in labs and publish what they say. Student voices can only be read by students who sign up with a university email address. Operated by bestiee Inc.
Learn more about LabLog ↗Search engines and AI may reference the basic lab info and rating summaries on this page and the description of LabLog. Student voices are for student members only. Automated collection by programs (scraping, or input to or training of AI) is prohibited under Article 8 of the Terms of Service. If you need data for research or analysis, please contact us.