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Analytical Chemistry Lab
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The lab analyzes the D- and L-forms of amino acids separately, and applies this to drug discovery and diagnosis.
AboutAbout the lab
Opening up drug discovery and diagnosis through chiral amino acids
The Analytical Chemistry Lab develops analytical technologies that distinguish and measure the D- and L-forms of amino acids, and applies them to drug discovery and the early diagnosis of disease.
The lab has also developed an analytical method for the trace amounts of D-amino acids that form inside proteins, and uses it in research on age-related diseases and anti-aging.
It also develops reagents for analysis, materials for separation, and analytical instruments.
Through industry-academia-government collaborative research, the lab also works on developing functional foods, beverages, and cosmetics.
Key terms
- D- and L-forms (enantiomers)
- Two forms of a molecule that are mirror images of each other. For a long time, it was thought that amino acids in the body exist only as L-forms
- Chiral amino acid metabolomics
- A technology that analyzes all amino acids with their D- and L-forms separated
- Chiral stationary phase
- A material for separation that the lab is developing to separate the D- and L-forms of all amino acids
NewsLab news
Prof. Hamase received the Society Award of the Japan Society for Analytical Chemistry
An assistant professor received a Research Encouragement Award and a student received an Outstanding Presentation Award at the 38th Biomedical Analytical Science Symposium
A student received the Kyushu Analytical Chemistry Young Researcher Award and the Kyushu Analytical Chemistry Encouragement Award
A student received a Student Outstanding Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
The lab changed its name from the Drug Discovery and Drug Development Industry-Academia-Government Collaboration Lab to the Analytical Chemistry Lab
ResearchResearch themes
Building on analytical technologies that distinguish and measure the D- and L-forms of amino acids, the lab conducts research on drug discovery, early diagnosis, and age-related diseases. It develops its own reagents and instruments for analysis, and through industry-academia-government collaboration extends this work to products such as functional foods.
*Illustrative imageAnalysis of chiral amino acids, and drug discovery and diagnosis
Using a technology that analyzes all amino acids with their D- and L-forms separated (chiral amino acid metabolomics), the lab finds new functional D-amino acids and extends them to drug discovery research. It also develops technologies for the early diagnosis of disease, focusing mainly on kidney diseases.
*Illustrative imageProtein isomerization and aging research
Proteins undergo structural changes and isomerization as a result of aging and disease. The lab has developed an analytical method to examine the formation of trace amounts of D-amino acids in proteins, and uses it to detect abnormalities that accompany aging, to analyze links with age-related diseases, and in anti-aging research.
*Illustrative imageDevelopment of new analytical reagents, separation materials, and instruments
To analyze trace amounts of D-amino acids in complex biological samples with high sensitivity and accuracy, the lab is developing new highly sensitive analytical reagents. It is also developing chiral stationary phases that separate the D- and L-forms of all amino acids, and micro-HPLC instruments.
*Illustrative imageDevelopment of functional foods, beverages, and cosmetics
Based on the discovery of functional D-amino acids, the lab is developing new functional foods, beverages, and cosmetics. Through industry-academia-government collaborative research, it is bringing a variety of products to the world.
MembersFaculty
The members of the Analytical Chemistry Lab are faculty, doctoral, master's, and undergraduate students, and international students and researchers.As of 2026
- ProfessorKenji Hamase
- Associate ProfessorTakeyuki Akita
- Assistant ProfessorManabu Nakazono
- Assistant ProfessorChiharu Ishii
- Assistant ProfessorAbedin Nuren
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “D-l-amino acids” Gianluca.molla / CC BY-SA 4.0 (cropped)
- Analysis of chiral amino acids, and drug discovery and diagnosis: “Discoveries from Asteroid Bennu- Media Briefing Graphics (SVS14772 - NASA Chiral Molecules V2)” NASA's Scientific Visualization Studio - NASA/Nicola Fox, Smithsonian Institution/Timothy McCoy, Natural History Museum, London/Sara Russell, NASA/GSFC/Daniel Glavin, NASA/GSFC/Jason Dworkin, NASA/GSFC/Rani Gran, eMITS/Dan Gallagher, Jacobs-JETS/Scott Eckley, Barrios Technology Ltd/Rachel Barry, ADNET Systems, Inc./Lonnie Shekhtman / Public domain (cropped)
- Protein isomerization and aging research: “The seven pillars of aging” David Gems & João Pedro de Magalhães / CC BY 4.0 (cropped)
- Development of new analytical reagents, separation materials, and instruments: “Hplc column” Kreecher / CC BY-SA 4.0 (cropped)
- Development of functional foods, beverages, and cosmetics: “Mixture for herbal tea 03” Miomir Magdevski / CC BY-SA 4.0 (cropped)
- Related lab (Green Chemistry Division Lab): “Pharmaceutical Chemistry Lab” 作者不詳 / Public domain (cropped)
- Related lab (Eco-Pharma Division Lab): “Active Transport - Protein Pumps” Christinelmiller / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
- Related lab (Environmentally Benign Medicinal Chemistry Lab): “Palladium on carbon” Marbletan / CC0 (cropped)
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