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International Chemical and Physical Pharmaceutical Sciences Lab
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A lab that creates biomolecules by introducing new functions into nucleic acids and proteins.
AboutAbout the lab
Giving biomolecules new functions
The International Chemical and Physical Pharmaceutical Sciences Lab (the Aso Lab) works on creating useful biomolecules by introducing new functions into biomolecules such as nucleic acids, peptides, and proteins.
The lab designs and synthesizes small organic molecules that carry functions, introduces them into biomolecules, and uses the resulting molecules to investigate how biomolecules work.
It also aims at applications in treating diseases and detecting disease states.
Key terms
- Reactive nucleic acid
- A nucleic acid with an added part that causes a chemical reaction. It uses its ability to recognize and bind proteins to modify a target protein.
- Lysine residue
- The part of a protein derived from lysine, one of the amino acids that make up proteins. Lysine residues are abundant on protein surfaces, making them well suited as modification sites.
- Chemical modification
- An operation that attaches another structure to a protein or similar molecule through a chemical reaction, giving it new properties such as fluorescence.
ResearchResearch themes
The lab aims to create biomolecules by introducing new functions into nucleic acids, which carry genetic information, and into peptides and proteins, which play diverse roles. Its goals are to use the resulting molecules to study how biomolecules work and to apply them to treating diseases and detecting disease states.
*Illustrative imageDesign and Synthesis of Functional Nucleic Acid Molecules
The lab designs and synthesizes reactive nucleic acids with added chemical reactivity, which specifically chemically modify target proteins. This research yields proteins carrying fluorescent groups or functional groups, leading to an understanding and control of their structure and function.
*Illustrative imageProtein Modification for Creating Biodrugs
Chemical modification of proteins for stabilization, targeting, or enhanced activity is an effective approach for pharmaceutical applications. The lab builds reactivity toward lysine residues into nucleic acids that recognize proteins, and uses them to carry out site-specific chemical modification of proteins.
*Illustrative imageDrug Molecules for Treating Bone Lesions
The lab synthesizes bisphosphonate derivatives with high affinity for bone and conjugates them to proteins and polymers that are effective for treating and diagnosing bone lesions. The research aims to create drug molecules that act specifically on bone lesions.
MembersFaculty
- Associate ProfessorMariko Aso
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Probable Nucleic Acid precipitated” michael / CC BY 2.0 (cropped)
- Design and Synthesis of Functional Nucleic Acid Molecules: “DNA microarray chip” ErikAbner / CC BY 4.0 (cropped)
- Protein Modification for Creating Biodrugs: “Protein Crystal Structure of the human Sec23a-24a heterodimer, complexed with the SNARE protein Sec22b PDB 2nup” Emw / CC BY-SA 3.0 (cropped)
- Drug Molecules for Treating Bone Lesions: “Bone Marrow (NIH BioArt 56)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Pharmaceutical Cell Biochemistry Lab): “Células de cebolla aumento total 100X en división celular” BioGenZambrano / CC BY-SA 4.0 (cropped)
- Related lab (Drug Molecular Design Lab): “Kandiszucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Related lab (Precision Molecular Transformation Chemistry Lab): “Positron Emission Tomography” Christkannada / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Biology Lab): “Blue-white test” Stefan Walkowski / CC BY-SA 4.0 (cropped)
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