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Drug Discovery Chemical Biology Lab
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The lab develops drugs that form covalent bonds with proteins and fluorescent molecules that visualize metabolism.
AboutAbout the lab
Analyzing and controlling living systems with new functional molecules.
The Drug Discovery Chemical Biology Lab synthesizes functional molecules of its own design and applies them to the analysis and control of biomolecules.
Combining chemical biology and medicinal chemistry, the lab studies covalent drugs, which form covalent bonds with proteins to inhibit their function.
The lab is also developing a new type of fluorescent probe that can visualize metabolism inside cells.
On the lab's website, it is presented under the name "Ojida Lab."
Key terms
- Covalent drug
- A drug that forms a covalent bond with its target protein and inhibits its function
- Fluorescent probe
- A molecule that emits light. A tool that makes a target substance or reaction inside cells visible by light
- Fatty acid β-oxidation
- One of the pathways by which cells produce energy. The series of reactions in which fatty acids are broken down
NewsLab news
Paper by a doctoral student published in Journal of the American Chemical Society Au
Master's student received an Outstanding Poster Award at the 36th Fukuoka Symposium
Master's student received a Poster Award at the 20th Annual Meeting of the Japan Society for Chemical Biology
Review article by an academic research fellow published in the journal of the Japanese Proteomics Society
Doctoral student received the BMC/BMCL Award at the 42nd Medicinal Chemistry Symposium
ResearchResearch themes
The lab freely synthesizes functional molecules of its own design and applies them to chemical biology research on the analysis and control of biomolecules. Combining chemical biology and medicinal chemistry, it studies covalent drugs and fluorescent probes that visualize metabolism inside cells.
*Illustrative imageDevelopment of Covalent Drugs
Using a reactive group called α-chlorofluoroacetamide (CFA), the lab examines whether it can bind selectively to a chosen target, taking the protein EGFR as an example.
*Illustrative imageFluorescent Probes for Metabolism
The lab is developing fluorescent probes that let researchers see metabolism inside cells by light. These molecules detect, in living cells, the activity of fatty acid β-oxidation, one of the pathways that produce energy.
MembersFaculty
The members of the Ojida Lab consist of faculty, academic research fellows, JSPS research fellows, technical staff, secretaries, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorAkio Ojida
- Assistant ProfessorShohei Uchinomiya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “COS-7 Cells - 40X Magnification - Confocal Microscopy” Joseph Elsbernd / CC BY 2.0 (cropped)
- Development of Covalent Drugs: “Covalent-drugs-silence-proteins” Dr. Juswinder Singh / CC BY-SA 3.0 (cropped)
- Fluorescent Probes for Metabolism: “Fluorescence of Riboflavin in Water” Ksenia Kandurova, Yurii Kandurov, Dmitry Stavtsev / CC BY 4.0 (cropped)
- Related lab (Physiology Lab): “Mitochondria 4 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Biology Lab): “Blue-white test” Stefan Walkowski / CC BY-SA 4.0 (cropped)
- Related lab (Precision Molecular Transformation Chemistry Lab): “Positron Emission Tomography” Christkannada / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
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