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Molecular Pathology Analysis Lab
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The lab uses lipid oxidation as a clue to explore disease mechanisms and drug discovery.
AboutAbout the lab
Exploring disease mechanisms and drug discovery through lipid oxidation
The Molecular Pathology Analysis Lab focuses on lipid oxidation in its drug discovery research and its search for biomarkers.
Lipid peroxides and their metabolites have been reported to act as causative molecules in various diseases and in inflammation.
For example, peroxides have been reported to be involved in ferroptosis, a newly identified form of cell death, and complexes of lipid-derived aldehydes and proteins have been reported to be involved in the onset of angiogenesis and age-related macular degeneration.
The lab first developed technologies for detecting oxidized lipids and for screening target molecules.
Recently, it has built on these technologies to verify candidate compounds in animal models of disease and to elucidate disease mechanisms.
Key terms
- Ferroptosis
- A form of cell death caused by iron-dependent lipid oxidation
- Lipid radical
- One of the substances formed when lipids are oxidized. It arises together with peroxides and aldehydes
- Theranostics
- A concept that combines therapeutics (treatment) and diagnostics (diagnosis)
NewsLab news
A master's student received the Hoshino Award (Outstanding Presentation Award) at the Biomedical Analytical Science Symposium
An undergraduate student received the Best Poster Award at the Kyushu Symposium on the Structure and Function of Proteins and Enzymes
An undergraduate student received an Outstanding Poster Award at the Kyushu Symposium on the Structure and Function of Proteins and Enzymes
An undergraduate student received an Outstanding Poster Award at the Kyushu Branch Meeting of the Japanese Biochemical Society
A master's student received an Outstanding Presentation Award (poster) at the joint meeting of the Japan Society for Oxidative Stress and the Japanese Society for Redox Medicine and Biology
ResearchResearch themes
The lab aims to carry out drug discovery research that meets unmet medical needs, and to search for biomarkers. Focusing on lipid oxidation as a clue, it develops technologies for detecting and analyzing oxidized lipids, and uses them to study disease mechanisms.
*Illustrative imageTechnologies for detecting and analyzing the structure of oxidized lipids
The lab developed a probe that emits fluorescence when it captures lipid radicals. It has recently extended this work to structural analysis of lipid radicals and to the detection and structural analysis of aldehydes, and plans to develop it into a biomarker search using patient samples.
*Illustrative imageDrug discovery targeting oxidized lipids
Eliminating lipid radicals, the starting point for the formation of oxidized lipids, reduced the onset and progression of chemical carcinogenesis and light-induced retinal damage. Based on this result, the lab built an inhibitor screening system, found candidate seed compounds for several diseases, and is working to elucidate the disease mechanisms.
*Illustrative imageExpansion into radicalomics research
The developed technologies can be applied not only to lipid radicals but also to protein radicals and DNA radicals. The lab has developed probes that comprehensively detect the radicals that first form when biofunctional molecules are oxidized, and is developing this into radicalomics research.
*Illustrative imageMolecular imaging and theranostics
The lab develops small-molecule compounds that enable multimodal imaging with magnetic resonance, fluorescence, and mass spectrometry. By integrating information across scales from living organisms to molecules, it aims to apply them to disease models. This approach will also be extended to theranostics.
MembersFaculty
The members of the Molecular Pathology Analysis Lab are faculty, technical staff, secretaries, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKen-ichi Yamada
- Assistant ProfessorJutanom Mirinthorn
- Assistant ProfessorEisho Kozakura
- Assistant ProfessorMasami Abe
- Assistant ProfessorLerksaipheng Pakawit
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Rust and dirt” Roger McLassus / CC BY-SA 3.0 (cropped)
- Technologies for detecting and analyzing the structure of oxidized lipids: “Biological Mass Spectrometry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Drug discovery targeting oxidized lipids: “The surface of highly curved lipid bilayer” Semen Yesylevskyy / CC BY 4.0 (cropped)
- Expansion into radicalomics research: “Free-radicals-oxygen” Healthvalue / CC BY-SA 3.0 (cropped)
- Molecular imaging and theranostics: “Fluorescence Imaging Experiment 02” Yurii Kandurov, Ksenia Kandurova, Dmitry Stavtsev / CC BY 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
- Related lab (Structural Analysis for Drug Discovery Lab): “Autism Aspect Pain Sensitivity 1” MissLunaRose12 / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacology Lab): “Glial cells in the mouse spinal cord” xtream1101 (archive user) / CC BY-SA 4.0 (cropped)
- Related lab (Cellular Biopharmacy Lab): “Environmental pollution Kaduna state” Verified legend / CC BY-SA 4.0 (cropped)
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