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Environmentally Benign Medicinal Chemistry Lab
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The lab makes molecules such as pharmaceuticals through environmentally friendly catalytic reactions.
AboutAbout the lab
Making pharmaceutical molecules with environmentally friendly catalytic reactions.
The Environmentally Benign Medicinal Chemistry Lab studies "environmentally benign catalytic reactions" for supplying functional molecules such as pharmaceuticals in ways that are gentle on the global environment.
Using the reactions it has developed as key steps, the lab also works on the efficient synthesis of bioactive natural products and pharmaceuticals.
The research rests on two strengths: the synthesis of organic compounds and the synthesis of metal complexes.
Based on green chemistry, the lab works to contribute to green drug discovery.
Key terms
- Environmentally benign catalytic reaction
- A catalytic reaction for supplying molecules such as pharmaceuticals in ways that are gentle on the global environment
- Ketimine
- An imine made from a ketone. An N-unprotected ketimine is one with no protecting group on the nitrogen
- Green Pharma
- Research that combines expanding the indications of existing approved drugs with the environmentally friendly synthesis of drugs
NewsLab news
Paper published in Tetrahedron. Chem.
Student received an Outstanding Poster Award at the 63rd Joint Kyushu Meeting of Chemistry-Related Branches
Student received a GSC Poster Award at the 15th JACI/GSC Symposium
Student received a Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Paper published in Org. Lett.
ResearchResearch themes
The lab develops "environmentally benign catalytic reactions" to supply functional molecules such as pharmaceuticals, which humanity needs, in ways that are gentle on the global environment, and uses them as key reactions for the efficient synthesis of bioactive natural products and pharmaceuticals. If inert functional groups can be selectively activated by a catalyst, activation and protection/deprotection steps can be omitted, making the reactions excellent in atom economy.
*Illustrative imageChemistry of N-Unprotected Ketimines
Using ketimines that carry no protecting group on nitrogen, the lab is developing reactions that directly produce unprotected amino acids and related compounds without a deprotection step. It has also developed an environmentally benign synthesis of the starting ketimines, and has succeeded in converting them to amines and amino acids without isolating them.
*Illustrative imageDirect Catalytic Transformation of Carboxylic Acids
Using copper and iron catalysts, the lab has developed reactions that convert the α-position of carboxylic acid derivatives into other functional groups. Recently it has turned to reactions of unprotected carboxylic acids, which require no installation or removal of directing groups, and has reported α-oxidation by an iron/alkali metal cooperative catalyst.
*Illustrative imageApplication to the Synthesis of Bioactive Compounds
The lab is applying the environmentally benign catalytic reactions it has developed to the synthesis of important bioactive compounds. Currently, using advanced technologies such as flow synthesis, it is developing methods that can supply these compounds practically even in limited space.
*Illustrative imageGreen Pharma and Drug Discovery Research
The lab aims to contribute, in the field of green chemistry, to the Green Pharma research promoted by Kyushu University's Faculty of Pharmaceutical Sciences. Drug discovery research on anticancer drugs, analgesics, and others is carried out as joint research.
MembersFaculty
The members of the Environmentally Benign Medicinal Chemistry Lab consist of faculty, secretaries, technical staff, postdoctoral researchers, researchers, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorTakashi Ohshima
- Associate ProfessorRyo Yazaki
- Assistant ProfessorTakuma Tagami
- Assistant ProfessorKeitaro Umeno
- Assistant ProfessorAkimasa Sugisaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Palladium on carbon” Marbletan / CC0 (cropped)
- Chemistry of N-Unprotected Ketimines: “Round bottom flask 500ml” Lilly_M / CC BY-SA 3.0 (cropped)
- Direct Catalytic Transformation of Carboxylic Acids: “Picture from an organic chemistry laboratory” Sil.d / CC BY 4.0 (cropped)
- Application to the Synthesis of Bioactive Compounds: “Hibiscus medicinal plant” Prathvi Acharya / CC BY-SA 4.0 (cropped)
- Green Pharma and Drug Discovery Research: “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Green Chemistry Division Lab): “Pharmaceutical Chemistry Lab” 作者不詳 / Public domain (cropped)
- Related lab (Green Pharma Division Lab): “Medicinal plant , farm Research of KHORRAMAN Pharmaceutical co. - panoramio” Shahram Gandabi / CC BY 3.0 (cropped)
- Related lab (Reaction-Driven Drug Discovery Chemistry Lab): “Fume hood and table of elements, early XX century Gdansk University of Technology” LukaszKatlewa / CC BY 4.0 (cropped)
- Related lab (Drug Molecular Design Lab): “Kandiszucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
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