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Structural Analysis for Drug Discovery Lab
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The lab studies the structures of biological supramolecules and searches for treatments for pain and itch.
AboutAbout the lab
The structures of biological supramolecules, and drug discovery for pain and itch
The Structural Analysis for Drug Discovery Lab studies the structures of biological supramolecules using electron microscopy, and searches for treatments for chronic pain and chronic itch.
In structural analysis, the lab uses cryo-electron microscopy to examine the shapes of complexes in which DNA and proteins are bound together.
In drug discovery, the lab analyzes the mechanisms that cause chronic pain and chronic itch, and searches for therapeutic drugs.
The lab also works on green pharma research, which includes the search for treatments for pain and itch.
Key terms
- Cryo-electron microscopy
- A type of electron microscopy. In this lab, it is used to examine the shapes of biological supramolecules, such as complexes of DNA and proteins
- Chronic pain
- A condition in which pain continues for a long time
- Chronic itch (chronic pruritus)
- A condition in which itching continues for a long time
ResearchResearch themes
The lab uses electron microscopy to analyze the structures of biological supramolecules, analyzes the mechanisms of chronic pain and chronic itch, and searches for therapeutic drugs. It also works on green pharma research, which includes the search for treatments for pain and itch.
*Illustrative imageStructural analysis of DNA-protein complexes
Lecturer Mayanagi uses cryo-electron microscopy to examine the shapes of complexes in which DNA and proteins are bound together, using a method called single-particle analysis.
*Illustrative imageChronic pain and itch, and the search for therapeutic drugs
Lecturer Yamashita analyzes the mechanisms that cause chronic pain and chronic itch, and searches for therapeutic drugs. The research keywords include Mas-related G protein-coupled receptors, ATP receptors, microglia, and dorsal root ganglion neurons.
*Illustrative imageGreen pharma research
The lab's research themes include green pharma research, which covers the search for treatments for pain and itch. The website that Lecturer Yamashita lists explains that it promotes open innovation in drug discovery based on promising seeds held by academia across the whole of Kyushu.
MembersFaculty
- LecturerKota Mayanagi
- LecturerTomohiro Yamashita
- Assistant ProfessorTomohito Tanihara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Autism Aspect Pain Sensitivity 1” MissLunaRose12 / CC BY-SA 4.0 (cropped)
- Structural analysis of DNA-protein complexes: “Cryo-EM structure of the human nucleosome 8KB5” Hirai S, Kujirai T, Akatsu M, Ogasawara M, Ehara H, Sekine SI, Ohkawa Y, Takizawa Y, Kurumizaka H / CC0 (cropped)
- Chronic pain and itch, and the search for therapeutic drugs: “Capsaicin oil” TiCPU / CC BY-SA 3.0 (cropped)
- Green pharma research: “12 Principles of Green Chemistry proposed by Anastas and Warner” Rajat Goyal, Archana Sharma, Vijay Kumar Thakur, Monika Ola, Prabodh Chander Sharma / CC BY 4.0 (cropped)
- Related lab (Pharmacokinetics Lab): “Pharmacy, Medicine Store, DrugsBank” ManzoorRph / CC BY-SA 4.0 (cropped)
- Related lab (Green Pharma Structural Analysis Lab): “Protein Structure of human NDNF” Alpha Fold Team / CC BY 4.0 (cropped)
- Related lab (Green Pharma Division Lab): “Medicinal plant , farm Research of KHORRAMAN Pharmaceutical co. - panoramio” Shahram Gandabi / CC BY 3.0 (cropped)
- Related lab (Molecular Pathology Analysis Lab): “Rust and dirt” Roger McLassus / CC BY-SA 3.0 (cropped)
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