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Molecular and Cellular Biology Lab
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The lab uses budding yeast to study gene expression, endoplasmic reticulum stress, and gamete formation.
AboutAbout the lab
Unraveling the regulation of life phenomena using budding yeast
The Molecular and Cellular Biology Lab uses budding yeast, a eukaryotic model organism, to elucidate the regulatory mechanisms of biological phenomena, aiming to contribute to medicine and healthcare.
The lab works on post-transcriptional regulation of gene expression, the signaling mechanisms that control the endoplasmic reticulum (ER) stress response, and the mechanisms of gamete formation.
Undergraduate students can join through graduation research in the College of Medical Sciences and the College of Biological Sciences, or through laboratory training in the College of Medicine.
On the lab's website, it is introduced under the name "Irie Lab."
Key terms
- Post-transcriptional regulation
- The regulation of mRNA stability and of translation into protein at stages after mRNA has been made from DNA
- Endoplasmic reticulum (ER) stress
- A critical condition for the cell in which proteins cannot fold correctly and accumulate in the ER as misfolded proteins
- Cellularization
- The process in which a multinucleate state is divided into individual cells through a special type of cell division. The shape of the nuclei and the plasma membrane change substantially
NewsLab news
A student received the FY2025 Global Education Institute Director's Award and the University of Tsukuba Meikeikai Award
A student's paper was published in The Journal of Physical Chemistry B as a collaboration with the Harada Lab at the Center for Computational Sciences
A student's paper was published in Bio-protocol
A student received a Best Presentation Award at the 12th CCR4-NOT Research Meeting
A student's paper was published in Cell Structure and Function, and a press release was issued
ResearchResearch themes
Using budding yeast, the lab investigates how gene activity is regulated, how cells respond to critical conditions, and what happens during the process of gamete formation. It aims to clarify the regulatory mechanisms of biological phenomena and to contribute to medicine and healthcare.
*Illustrative imagePost-transcriptional regulation of gene expression
Among the ways gene expression is regulated, the lab focuses on the control of mRNA stability and of translation into proteins. Using budding yeast, it aims to clarify regulatory mechanisms in response to various stresses.
*Illustrative imageSignal transduction in the ER stress response
The lab studies the ER stress response, which cells are equipped with to cope with ER stress. Using budding yeast, it investigates the signal transduction mechanisms that control this response.
*Illustrative imageMechanisms of gamete formation
The lab seeks to clarify the mechanism of cellularization during meiosis and sporulation in budding yeast. In cellularization, the organization inside the cell changes dramatically, including changes in nuclear morphology and remodeling of the plasma membrane.
MembersFaculty
The Molecular and Cellular Biology Lab consists of faculty members, graduate students, and undergraduate students.As of 2026
- ProfessorKenji Irie
- Project ProfessorToshiyasu Shimomura
- Associate ProfessorTomoaki Mizuno
- Associate ProfessorYasuyuki Suda
- Assistant ProfessorTakaho Tsuchiya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Yeast Cells in Wet Mount Microscopy of Culture” Ajay Kumar Chaurasiya / CC0 (cropped)
- Post-transcriptional regulation of gene expression: “Baking yeast cells under 40x microscope objective” ~delta / CC BY-SA 4.0 (cropped)
- Signal transduction in the ER stress response: “0313 Endoplasmic Reticulum a en” OpenStax / CC BY 3.0 (cropped)
- Mechanisms of gamete formation: “Prepared slide showing stages of meiosis under a compound microscope” Knowledge genome / CC BY-SA 4.0 (cropped)
- Related lab (分子環境生理学): “PonceauMembrane” Argymeg / CC BY-SA 3.0 (cropped)
- Related lab (解剖学・発生学): “Laboratory microcentrifuge tubes and pipette tips 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (分子寄生虫学): “Trypanosoma brucei brucei SEM” Sue Vaughan / CC BY 4.0 (cropped)
- Related lab (細胞情報制御学): “Confocal microscope AR” Ciphers / CC BY 3.0 (cropped)
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