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Gene Regulation Lab
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A lab that explores the mechanisms of gene expression through transcription and chromatin.
AboutAbout the lab
Exploring gene expression, the foundation of life
The Gene Regulation Lab studies gene expression, which lies at the foundation of biological phenomena, using biochemical and molecular biological methods.
It investigates transcription factors involved in transcriptional regulation, structural remodeling of chromatin (the site of transcription), and the mechanisms of iPS cell induction.
As one of its research topics, the lab also studies how brown adipocytes and beige cells differentiate, aiming to contribute to solving obesity.
The lab's website states that it provides careful, individual guidance to each graduate student, regardless of which university or department they come from.
Key terms
- Transcription
- The first of several steps in gene expression, and the process at the center of its regulation.
- Chromatin
- The condensed structure that DNA forms in eukaryotes. Remodeling of this structure plays an important role in regulating transcription.
- Brown adipocytes
- Fat cells rich in mitochondria that produce heat instead of ATP through the action of UCP-1.
- Beige cells
- Brown-fat-like cells interspersed in white adipose tissue. They highly express UCP-1 and produce heat in response to stimuli such as cold.
NewsLab news
Paper on a method for removing Sendai virus vectors published in Journal of Biotechnology
Paper on a direct reprogramming system for chondrocytes published in Scientific Reports
Paper on Sendai virus vectors controllable by Csy4 published in Journal of Biological Engineering
ResearchResearch themes
Organisms have a great many genes, but they express and use the genes they need only when they need them. Using biochemical and molecular biological methods, the lab aims to elucidate the mechanisms that regulate gene expression, studying transcriptional regulation, structural remodeling of chromatin, and the mechanisms of iPS cell induction.
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MembersFaculty
The members of the Gene Regulation Lab consist of faculty and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKen Nishimura
- Associate ProfessorAya Fukuda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Centrifuge tubes ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Mechanisms of adipocyte differentiation: “Scientist checks cell culture flask on microscope” Peter Saxon / CC BY-SA 4.0 (cropped)
- Related lab (Regenerative Stem Cell Biology Lab): “Laboratory Incubator; from a medical laboratory in Abuja, Nigeria” Frankincense Diala / CC0 (cropped)
- Related lab (Anatomy and Embryology Lab): “Laboratory microcentrifuge tubes and pipette tips 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Immunology Lab): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Molecular Pathology Lab): “Laminar flow hood 2” TimVickers / Public domain (cropped)
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