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74 labs · 17 student voices
Faculties at Institute of Science Tokyo ›
Kan Tanaka, Professor
0 student voices
The Tanaka-Yoshida Lab studies the cell, the basic unit of life, across a wide range of organisms from bacteria and algae to plants. At the foundation of the cellular system are mechanisms for acquiring energy, represented by respiration and the light reactions of photosynthesis. Supported by these, biosynthesis allows cells to grow and then proliferate. The lab aims to understand not just the individual parts but the fundamental mechanisms by which they work together to sustain life, and ultimately to design cells at will.
Yoh-Ichi Tagawa, Associate Professor
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The Tagawa Lab studies how to reproduce, outside the body, tissues made of multiple types of cells. Cell biology to date has cultured a single type of cell and used it for research. This lab aims to go further and turn assemblies of interconnected tissues into a single living system. It builds culture models of the liver and intestine as devices, and works on drug metabolism and on creating disease models of intestinal inflammation and viral infection.
Noriyuki Asakura, Associate Professor
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The Asakura Lab aims to drive enzymes with light energy to produce useful substances and energy. Its focus is electron transfer reactions, in which electrons are passed from one molecule to another. The lab studies the mechanisms of electron transfer in photosensitizers, electron carriers, and oxidoreductases. Building on this, it is working to assemble reaction systems with high energy conversion efficiency on solid surfaces.
Nobuhiro Nakamura, Associate Professor
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The Nobuhiro Nakamura Lab studies how animal tissues and cells maintain their structure and function, starting from intracellular signal transduction. It aims to clarify at the molecular level how disease arises when these mechanisms go awry. The lab combines experimental methods from molecular biology, cell biology, histochemistry, and animal physiology. Its main clues are receptors that receive stimuli from outside the cell and ubiquitination, which tags proteins with a marker.
Yatsunami Rie, Associate Professor
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The Yatsunami Lab studies how to enhance the function of enzymes produced by extremophiles through protein engineering. The lab also works on producing useful substances through metabolic engineering of extremophiles. Its main subjects are the extremely halophilic archaeon known in Japanese as "sankaku-kin" (the "triangle microbe"), which has the odd shape of a flat triangular plate, along with alkaliphilic bacteria and thermophiles. Microorganisms from extreme environments have special abilities that ordinary microorganisms lack, such as enzymes that work well under alkaline conditions.
Mie Shimojima, Associate Professor
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The Shimojima Lab studies how plants and algae synthesize and metabolize lipids, and what these lipids do. Lipids not only store energy but also form biological membranes and play a role in transmitting signals. The lab examines how plants change their lipids in response to environmental conditions such as temperature, drought, and nutrient deficiency. Drawing on this knowledge, it also aims to build systems that let plants and algae produce large amounts of useful lipids.
Satoshi Murakami, Professor
0 student voices
The Murakami Lab studies the three-dimensional structures of proteins using X-ray crystallography to understand how they function. Although proteins are built from combinations of just 20 amino acids, they carry out complex functions. The lab focuses mainly on membrane proteins, which sit in the cell membrane and handle the exchange of substances and information. To tackle targets that are hard to analyze, the lab also refines its techniques for producing, purifying, and crystallizing proteins.
Hata Takeshi, Associate Professor
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The Hata Lab develops new synthetic methods to synthesize and transform organic molecules exactly as desired. Using these methods, the lab synthesizes molecules with diverse functions, such as natural organic compounds and artificial pharmaceuticals. It emphasizes making them efficiently in few steps, and using safe reagents to reduce unnecessary waste. The lab aims to contribute to next-generation "manufacturing" that is essential for a sustainable society.
Kohji Seio, Professor
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The Seio Lab uses synthetic organic chemistry to develop functional molecules whose nucleic acid chemical structures have been modified. Nucleic acid therapeutics, which use chemically synthesized nucleic acids as drugs, are attracting attention, and the lab works to improve this technology. The lab designs chemical modifications that improve binding to target RNA and resistance to degradation. It also works on making nucleotide signaling molecules and tools for studying the functions of nucleic acids.
Takafumi Ueno, Professor
0 student voices
The Ueno Lab studies how to use chemistry to functionalize the assemblies formed when proteins gather spontaneously. Protein assemblies are used as functional materials in many places in nature. The lab investigates in detail how they are formed and what their structures are, and, incorporating computational design, creates new biomaterials. These efforts have yielded precisely moving molecular machines, artificial enzymes that surpass natural ones, and molecular cages that store target proteins.
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