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74 labs · 17 student voices
Other departments in School of Life Science and Technology ›Faculties at Institute of Science Tokyo ›
Toshiki Sawada, Professor
1 student voices
The Sawada Lab studies biomolecules whose sequences and structures can be designed, such as peptides and filamentous phages. Centered on molecular recognition and self-assembly, the lab combines genetic engineering with chemical synthesis and modification to clarify how sequence, interactions, assembled structure, and function are related. Research is experiment-driven: the lab quantitatively evaluates structure, physical properties, and function, and uses statistical analysis and machine learning where needed to interpret the results. The findings are fed back into the next round of molecular design and extended to biomedical applications, molecular sensing, and functional soft materials.
Shoen Kume, Professor
1 student voices
The Kume-Shiraki Lab studies how to create digestive organs, such as the pancreas, liver, and intestine, in a test tube. The starting materials are mouse and human ES cells and iPS cells. By generating cells that function as they do in the body, the lab aims to uncover the mechanisms of development and differentiation and to produce cell sources for regenerative medicine. The cells it creates can also serve as models of human development and differentiation, and can be applied to drug discovery and medicine.
Kosuke Fujishima, Associate Professor
1 student voices
The Fujishima Lab studies questions about the origin and evolution of life using synthetic biology, molecular and chemical evolution, and computational science. It seeks to uncover how highly functional macromolecules such as proteins and RNA arose and have been maintained. In test tubes, the lab reconstructs primitive proteins and RNA and their precursors, and examines their properties. At the same time, it works on creating novel functional molecules that life on Earth has not yet tried.
Taiko To, Associate Professor
1 student voices
The To Lab studies epigenetics, the mechanisms that regulate gene activity without changes to the DNA sequence. Using plants and fission yeast as materials, the lab investigates how organisms distinguish genes from harmful sequences within the genome. It also seeks to clarify how such modifications are passed on to the next generation and what environmental fluctuations do to the epigenome. Building on the results of basic research, the lab is also taking on the development of technologies for deliberately rewriting the epigenome.
Koshikawa Naohiko, Professor
1 student voices
The Koshikawa Lab investigates how cancer cells acquire malignant traits, using multifaceted approaches that are not bound by traditional disciplines. The lab focuses on membrane-type matrix metalloproteinase-1 (MT1-MMP), an enzyme on the cell surface that cleaves other membrane proteins. It is systematically examining how the diverse malignant traits of cancer arise through processing, in which MT1-MMP partially cleaves proteins. The lab aims to develop its basic research into translational research and to create novel cancer treatments and diagnostics.
Kiyohiko Kawai, Professor
1 student voices
The Kawai Lab conducts chemical biology research that makes full use of photochemistry, with the keywords "molecules," "fluorescence," and "single-molecule measurement." When fluorescent molecules are observed one at a time, each shows a characteristic way of emitting light: fluorescence blinking. Focusing on this blinking, the lab aims to understand and control the motion and chemical reactions of biomolecules. Within the lab, it works end to end, from organic synthesis and evaluation of photophysical properties to microscopy measurements, computational science, and time-series data analysis.
Kamiya Mako, Professor
1 student voices
The Kamiya-Asanuma Lab researches the creation of photofunctional molecules with new functions, based on chemistry. From the standpoint of chemical biology, a field that merges chemistry and biology, the lab develops chemical probes whose optical properties change when they react with biomolecules inside cells. The lab designs fluorescent probes and Raman probes and goes as far as applying them to biological observation. Organic synthesis of new compounds, evaluation of optical properties, and biological application are all carried out within a single lab.
Tomoaki Matsuura, Professor
1 student voices
The Matsuura Lab combines the parts that make up living organisms to build cell-free molecular systems specialized for specific functions. The lab then uses these cell-free molecular systems to evolve proteins and the molecular systems themselves. Through this work, the lab aims to clarify the properties of protocells, which are thought to have existed at the very beginning of life. At the same time, the lab also works on assembling molecules and molecular systems that can contribute to practical applications.
Hideki Taguchi, Professor
1 student voices
The Taguchi Lab studies the 'life of a protein': how proteins are born, take shape, and are broken down inside cells. Proteins are chains of amino acids, and they function only after folding into a defined three-dimensional structure. The lab investigates molecular chaperones, which assist folding, and the behavior of nascent chains that are still being synthesized on the ribosome. Aggregates formed when folding fails, such as amyloids and prions, are also objects of study.
Nobuhiro Hayashi, Professor
1 student voices
The Hayashi Lab regards life as a system made of proteins and conducts research focused on proteins. This is because the lab holds that the properties and state of a cell are determined by the types, amounts, and states of the proteins in it. The lab aims to put proteomics, a technology for analyzing proteins collectively, into practical use and apply it to diagnosis and treatment. It also works on developing artificial antibodies based on a new concept.
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