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Seio Lab
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The lab reworks the structures of nucleic acids to create new drugs and molecular tools.
AboutAbout the lab
Changing nucleic acid structures to create new functions.
The Seio Lab uses synthetic organic chemistry to develop functional molecules whose nucleic acid chemical structures have been modified.
Nucleic acid therapeutics, which use chemically synthesized nucleic acids as drugs, are attracting attention, and the lab works to improve this technology.
The lab designs chemical modifications that improve binding to target RNA and resistance to degradation.
It also works on making nucleotide signaling molecules and tools for studying the functions of nucleic acids.
Key terms
- Nucleic acid
- DNA and RNA. Biomolecules that carry genetic information and act as copies of it.
- Antisense oligonucleotide
- A drug that uses a short artificial nucleic acid to bind to a target RNA and suppress its function.
- Nucleotide
- A building block of nucleic acids, made of a base, a sugar, and a phosphate. It also serves as a signal in the body.
NewsLab news
A master's student received the Outstanding Poster Presentation Award at the Young Researchers' Meeting of the Division of Biofunctional Chemistry
Research results published in Org. Biomol. Chem.
A doctoral student received the Student Outstanding Presentation Award at the Annual Meeting of the Pharmaceutical Society of Japan
Research results published in Bioconjugate Chemistry
A master's student received the Takamiya Award for fiscal 2025
ResearchResearch themes
Centered on organic chemistry and nucleic acid chemistry, the lab pursues a wide range of work from basic to applied research. It originally designs and synthesizes chemical structures of nucleic acids, which leads to improved nucleic acid therapeutics and the development of tools for studying nucleic acid function.
*Illustrative imageModified Nucleic Acids for Antisense Oligonucleotides
To turn antisense oligonucleotides into drugs, many properties must be improved, including binding affinity and selectivity for the target RNA, resistance to degrading enzymes, and reduced side effects by suppressing binding to proteins. The lab designs original chemical modifications for the nucleobase, sugar, and backbone of nucleic acids and develops routes to synthesize them.
*Illustrative imageDeveloping Tools to Study Nucleic Acid Function
Living organisms contain nucleotides and nucleic acids with a variety of functions. Applying synthetic techniques cultivated over many years, the lab makes molecular tools by attaching labeling agents, fluorescent agents, and crosslinking agents to them, and uses these tools in collaborative research.
*Illustrative imageDeveloping Nucleic Acid Therapeutics for Disease
Drawing on the artificial nucleic acids it has developed and its broad knowledge and experience of nucleic acids, the lab collaborates with various research groups on project research to develop nucleic acid therapeutics for specific diseases, aiming at practical use.
MembersFaculty
Members of the Seio Lab include faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKohji SeioPublications ↗
- Assistant ProfessorEitaro MurakamiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Синтезатор олигонуклеотидов колоночный” Mfomich / CC BY-SA 3.0 (cropped)
- Modified Nucleic Acids for Antisense Oligonucleotides: “Adenosine-triphosphate-3D-balls” Jynto / CC0 (cropped)
- Developing Tools to Study Nucleic Acid Function: “LSM fluorescence image of HeLa immortalized cells showing fluorescent staining of cellular compartments. Nuclei are labeled in blue, the cytoplasm in orange, and vesicular transport–associated proteins in red” WillredDallto / CC BY-SA 4.0 (cropped)
- Developing Nucleic Acid Therapeutics for Disease: “DNA Orbit Animated Clean” Circli / CC BY-SA 4.0 (cropped)
- Related lab (正木研究室): “DNA Helix CPK” Ude / Public domain (cropped)
- Related lab (湯浅研究室): “Dispersion of White Light Through a Prism” Aligatorigiganti / CC0 (cropped)
- Related lab (藤田研究室): “Drosophila melanogaster under microscope” Talita Oliveira / CC BY-SA 4.0 (cropped)
- Related lab (山吉研究室): “DNA double helix horizontal” Jerome Walker / Public domain (cropped)
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