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Nobuhiro Nakamura Lab
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A lab that clarifies, at the molecular level, intracellular signal transduction and the diseases that arise when it goes wrong.
AboutAbout the lab
From cell signaling to the mechanisms of disease.
The Nobuhiro Nakamura Lab studies how animal tissues and cells maintain their structure and function, starting from intracellular signal transduction.
It aims to clarify at the molecular level how disease arises when these mechanisms go awry.
The lab combines experimental methods from molecular biology, cell biology, histochemistry, and animal physiology.
Its main clues are receptors that receive stimuli from outside the cell and ubiquitination, which tags proteins with a marker.
Key terms
- G protein-coupled receptor
- A membrane protein that receives stimuli from outside the cell and relays that information into the cell
- Knockout mouse
- A mouse in which a specific gene has been made nonfunctional. It is used to study the role of that gene
- Ubiquitination
- A reaction that attaches a small protein called ubiquitin as a marker. It switches proteins between degradation and transport
ResearchResearch themes
The lab investigates the intracellular signaling mechanisms that maintain homeostasis of the structure and function of animal tissues and cells. It aims to clarify, at the molecular level, the pathogenic mechanisms of conditions caused by abnormalities in these mechanisms.
*Illustrative imageThe Role of the Receptor ADGRF5 and Disease
The lab studies ADGRF5, a G protein-coupled receptor that transmits extracellular stimuli into the cell. Its roles in the lung and adipose tissue have been clarified, but it is still unknown why it is present in capillaries throughout the body, so the lab is exploring its function in blood vessels by analyzing knockout mice.
*Illustrative imageNovel Genes Expressed Under Stress and Infection
The lab has discovered novel genes whose expression is induced when cells are exposed to toxic substances or respond to infection. Hypothesizing that these genes regulate detoxification or immune responses, the lab is searching for the mechanisms that induce their expression and the molecules involved.
*Illustrative imageUbiquitination That Shapes Organelles
The lab has identified ubiquitinating enzymes and deubiquitinating enzymes located in mitochondria, endosomes, and the endoplasmic reticulum. It is analyzing how these enzymes are involved in regulating the characteristic shape and function of each organelle.
MembersFaculty
The members of the Nobuhiro Nakamura Lab consist of faculty members, postdoctoral researchers, and doctoral, master's, and undergraduate students.As of 2026
- Associate ProfessorNobuhiro NakamuraPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Multicolor fluorescence image of a living PC-12 cell” 8x57is / CC BY-SA 4.0 (cropped)
- The Role of the Receptor ADGRF5 and Disease: “Muscarinic receptor M2 coupled to protein G - 6OIK” Vcilleros / CC BY-SA 4.0 (cropped)
- Novel Genes Expressed Under Stress and Infection: “DNA Orbit Animated Clean” Circli / CC BY-SA 4.0 (cropped)
- Ubiquitination That Shapes Organelles: “E3 ubiquitin-protein ligase RNF123 - 2MA6” Ramelot, T.A., Yang, Y., Janjua, H., Kohan, E., Wang, H., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG) / CC0 (cropped)
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- Related lab (堤研究室): “PDB 1dng EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped)
- Related lab (中戸川研究室): “S cerevisiae septins” Spitfire ch, Philippsen Lab, Biozentrum Basel / Public domain (cropped)
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