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74 labs · 17 student voices
Faculties at Institute of Science Tokyo ›
Yoshitaka Ishii, Professor
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The Ishii Lab uses solid-state NMR spectroscopy to study the mechanisms of life phenomena from molecular structure at the atomic level. A particular focus is determining the structure of amyloid-β protein, which is considered a main cause of Alzheimer's disease. The lab also develops its own new solid-state NMR methods that improve measurement sensitivity and resolution. The lab also collaborates with RIKEN and labs overseas, so people interested in physical chemistry or computer science can also make full use of their strengths.
Kato Akira, Associate Professor
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The Kato Lab studies how diverse animals, mainly fish, adapt to environmental change and maintain homeostasis in the body. The key is the epithelial transport systems in the kidney, digestive tract, and gills. Epithelial cells finely regulate the movement of water, ions, and nutrients in and out of the body, and these basic mechanisms are broadly shared from fish to humans. The lab forms hypotheses from genome information and gene expression data, and tests them with methods such as molecular cell biology and electrophysiology.
Junji Hirota, Professor
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The Hirota Lab studies the neural mechanisms of the chemical senses, focusing on olfaction, the sense of smell. It uses mouse genetic approaches that combine genetic engineering and embryo engineering with imaging that makes cells glow. The lab is also developing a new genome engineering technology, the Bacillus subtilis genome (BGM) vector, for handling long DNA. By actually seeing gene activity and neural circuits, the lab approaches the mysteries of olfaction.
Masaaki Wachi, Professor
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The Wachi Lab studies bacterial cells to address the question "What is life?" This is because the lab considers the most essential property of life to be replicating itself and multiplying. It investigates why Escherichia coli always divides at the center of the cell and how the bacterial cell cycle proceeds. The lab also searches for new antibiotics and studies how bacteria can be made to produce an ingredient of umami seasoning.
Takashi Suzuki, Professor
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The Suzuki Lab studies how the neural circuits that underlie our perception, memory, and thinking are built. The lab's model system is the visual system of the fruit fly (Drosophila). It investigates how axons recognize their partners and form synapses, and how synapses change in response to experience. The lab approaches these questions by combining genetic engineering, cell engineering, biochemistry, and light-based imaging methods.
Tachibana Kazunori, Associate Professor
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The Tachibana Lab uses Cladonema, a small jellyfish, to study the basic mechanisms of animals. Its subjects include light-controlled spawning, the rhythm of egg production, sleep, lifespan, self/non-self recognition, and sex determination. Day to day, the work is basically raising jellyfish, and on top of that the lab analyzes gene sequences and observes tissues under a microscope. Lab members also build their own programs for analyzing behavior recordings, using small computers and Python.
Hiroshi Kimura, Professor
0 student voices
Kimura Lab studies why cells that carry the same genetic information take on different forms and functions. The key is chemical modification of histones, the proteins that DNA wraps around. These modifications change how genes function and are passed on through cell division. This phenomenon is called epigenetics. The lab develops methods to observe histone modifications and transcription in living cells and organisms, and investigates their significance and regulatory mechanisms.
Yuichi Hongoh, Professor
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Hongoh Lab studies the physiology and ecology of communities of microbes in the environment that are difficult to culture. It is said that more than 99% of the microbes on Earth have no known method of cultivation. The lab investigates the relationships between the protists that digest wood in termite guts and the bacteria and archaea that live in symbiosis with them. It also targets microbial communities living in glaciers and snow, using methods such as metagenomics and single-cell genomics.
Takashi Hirasawa, Associate Professor
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Hirasawa Lab works on metabolic engineering, using microbes as hosts to produce useful substances. Microbial cells multiply quickly and have highly active metabolism, which makes them excellent hosts for manufacturing. Having microbes produce substances that have been made chemically is expected to help build a circular society. Targeting Escherichia coli, coryneform bacteria, and budding yeast, the lab handles everything from strain breeding to developing production-process technologies.
Mikiko Tanaka, Professor
0 student voices
The Tanaka Lab approaches the question of how body forms evolved by studying the mechanisms of development. Changes in animal form involve changes in developmental programs, so the lab analyzes the development of species that occupy key positions in the evolutionary tree. Its main model is the limb: hands and feet evolved from the pectoral and pelvic fins of ancient fish. In addition to chickens, zebrafish, and medaka, the lab works with many other animals, including cloudy catsharks, emus, and softshell turtles.
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