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Ueno Lab
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The lab uses chemistry to functionalize protein assemblies and create new biomaterials.
AboutAbout the lab
Functionalizing protein assemblies through chemistry.
The Ueno Lab studies how to use chemistry to functionalize the assemblies formed when proteins gather spontaneously.
Protein assemblies are used as functional materials in many places in nature.
The lab investigates in detail how they are formed and what their structures are, and, incorporating computational design, creates new biomaterials.
These efforts have yielded precisely moving molecular machines, artificial enzymes that surpass natural ones, and molecular cages that store target proteins.
Key terms
- Protein assembly
- A complex, precise structure formed when multiple proteins gather on their own.
- Self-assembly reaction
- A reaction in which molecules gather on their own to form an assembly of a defined shape.
- Artificial metalloenzyme
- A protein with an incorporated metal that can carry out chemical reactions not found in nature.
NewsLab news
Research results accepted in Small Structures
Research results published in Angew. Chem. Int. Ed.
Research results published in Advanced Science
A paper from the lab received the Research Paper Award of the Tejima Seiichi Memorial Research Award at Tokyo Institute of Technology
An Assistant Professor received the Doctoral Thesis Award of the Tejima Seiichi Memorial Research Award at Tokyo Institute of Technology
ResearchResearch themes
Focusing on protein assemblies, which are used as functional materials in many places in nature, the lab advances their engineering, precise structural analysis, and functional analysis through computational design and molecular dynamics. It aims to create innovative functional protein materials that solve problems in biotechnology and energy.
*Illustrative imageProtein Assemblies and Biomaterials
Protein assemblies form through self-assembly reactions in which multiple proteins gather spontaneously. The lab investigates how precise assemblies form in crowded environments full of molecules, such as the inside of a cell. It artificially makes needle-, cage-, and lattice-shaped assemblies and develops applications that could lead to vaccine development.
*Illustrative imageMetal Function and Applications to Solid Materials
The lab focuses on how the molecular space created by protein assemblies precisely controls the reactivity of metals. It has developed artificial metalloenzymes that carry out in water reactions that normally proceed only in organic solvents, and it is also taking on artificial photosynthesis and molecular tools for recovering rare trace metals.
*Illustrative imagePrecise Structural Analysis and Computational Science
Using cutting-edge measurement methods such as X-ray free-electron lasers and high-speed atomic force microscopy, the lab aims to capture everything from chemical reactions on the nanosecond and angstrom scale to assembly reactions on the millisecond and nanometer scale. Supercomputer calculations are also essential for designing assemblies and elucidating reaction mechanisms.
MembersFaculty
Members of the Ueno Lab include faculty members, postdoctoral researchers, doctoral, master's, and undergraduate students, technical staff, and secretaries.As of 2026
- ProfessorTakafumi UenoPublications ↗
- Assistant ProfessorKosuke KikuchiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
- Protein Assemblies and Biomaterials: “Comparison of ferritin and transferrin” Rala.atulk / CC BY-SA 3.0 (cropped)
- Metal Function and Applications to Solid Materials: “Natural Copper Ore Macro 1” “Jon Zander (Digon3)" / CC BY-SA 3.0 (cropped)
- Precise Structural Analysis and Computational Science: “Sp8-3972” Nnn / CC BY-SA 3.0 (cropped)
- Related lab (金原研究室): “Lipid Bilayer” US gov / Public domain (cropped)
- Related lab (小畠・三重研究室): “1RRX pdb group” Christopher King / CC BY 3.0 (cropped)
- Related lab (中村・岡田研究室): “Boron neutron capture therapy (bnct) illustration” Pat Kenny (Illustrator) / Public domain (cropped)
- Related lab (山口研究室): “DAPI-stained nuclei of HeLa cells” DrBib / CC BY 4.0 (cropped)
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