Labs in The University of Osaka, Graduate School of Pharmaceutical Sciences

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The lab designs next-generation antibody therapeutics based on how antibodies bind to their targets.

The Antibody Therapeutics Design Lab takes the binding mode, meaning where and how an antibody binds to its target, as the object of analysis and design, and conducts research aimed at creating next-generation antibody therapeutics. By combining its proprietary "epitope-homogenized antibody panel" technology with AI-based structural modeling, the lab is shifting from empirical exploration to rational design. Focusing on intractable diseases such as cancer, immune disorders, and infectious diseases, the lab's main drug discovery targets are membrane proteins such as GPCRs and immune checkpoint molecules. The lab's website is the "Antibody Design Project" page of the National Institutes of Biomedical Innovation, Health and Nutrition, which lists related links for the Osaka University Cooperative Graduate School (Biomedical Innovation Science chair).

#Antibody therapeutics #Binding modes #AI structural modeling

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核輸送動力学分野 (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.

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The lab carries out everything from artificial nucleic acid synthesis to screening, aiming to develop nucleic acid therapeutics.

The Nucleic Acid Therapeutics Design Lab studies the development of nucleic acid therapeutics that use artificially made nucleic acids. The lab works on synthesizing artificial nucleic acids to be introduced into nucleic acid therapeutics such as antisense nucleic acids and aptamers, and on developing screening methods to efficiently select promising sequences. Because nucleic acid therapeutics can target almost any molecule in the body, including DNA, RNA, and proteins, they are expected to lead to the development of highly effective drugs for intractable diseases that are difficult to treat with existing methods. The lab's website presents it as the "Artificial Nucleic Acid Screening Project" of the National Institutes of Biomedical Innovation, Health and Nutrition, and students from the Graduate School of Pharmaceutical Sciences at Osaka University join as cooperative graduate students.

#Nucleic acid therapeutics #Artificial nucleic acids #Aptamers

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The lab discovers drug targets for antibody therapeutics and develops the underlying technologies.

The Drug Target Discovery Lab studies foundational technologies for developing biopharmaceuticals such as antibody therapeutics. In particular, the lab works on discovering molecules that can serve as targets for antibody therapeutics and on developing new types of antibody derivatives based on antibodies. The lab operates as the Biopharmaceutical Discovery Project of the National Institutes of Biomedical Innovation, Health and Nutrition, and accepts graduate students as a field of the cooperative graduate school of the Graduate School of Pharmaceutical Sciences at Osaka University. The lab's website introduces it under the name "Biopharmaceutical Discovery Project." The research content is based on the website's description from around 2022.

#Antibody therapeutics #Drug target discovery #Phage display

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A lab that uses computers to tackle drug discovery and the mechanisms of disease.

The Mizuguchi Lab conducts research and technology development that use computers to make drug development more efficient, and works to elucidate the mechanisms of disease. The lab does not conduct any experiments using animals or microorganisms; its research is carried out entirely with computers. This field is called bioinformatics, and the lab aims to contribute to drug development in collaboration with researchers who conduct experiments. On the website, the lab is listed under the name "Mizuguchi Lab" (Computational Biology Lab, Institute for Protein Research).

#Bioinformatics #Data integration #Drug discovery

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A lab that uses primates in medical research, aiming to control diseases.

The Primate Medical Science Lab is a cooperative graduate school field of the Graduate School of Pharmaceutical Sciences, Osaka University, and is based at the National Institutes of Biomedical Innovation, Health and Nutrition. The institute's Research Center for Primate Medical Science conducts medical research using primates across a broad range, from basic research to putting the results to practical use in medicine. With disease control as its ultimate goal, the center also works on creating disease models and on vaccine development. The center has labs for infectious diseases, genetic diseases, reproduction, and genome analysis.

#Primates #Disease models #Infectious diseases

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A graduate school field of the Graduate School of Pharmaceutical Sciences, connected with the National Institutes of Biomedical Innovation, Health and Nutrition.

The Medicinal Plant Resources Lab is a cooperative graduate school field of the Graduate School of Pharmaceutical Sciences, Osaka University, and is part of the Division of Biomedical Innovation Science. On the Graduate School of Pharmaceutical Sciences' lab introduction page, the name of the National Institutes of Biomedical Innovation, Health and Nutrition, a National Research and Development Agency, appears alongside this division. The website introduced as the lab homepage of the affiliated institution is that of the institute's Research Center for Medicinal Plant Resources.

#Medicinal plant resources #Cooperative graduate school

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A lab that uses cells made from stem cells to study the efficacy and toxicity of drugs.

The Stem Cell Regulation Lab conducts research to build systems that evaluate the efficacy and toxicity of drugs, using blood cells, hepatocytes, and other cells differentiated from stem cells such as ES cells and iPS cells. Its aim is to accelerate drug discovery research. While clarifying the molecular mechanisms of development, the lab applies the information obtained to developing methods for inducing stem cell differentiation and to drug discovery. On the website of the National Institutes of Biomedical Innovation, Health and Nutrition, the lab is introduced under the name “Cell Models for Drug Discovery Research Project.”

#Stem cells #Differentiation induction #BBB models

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A lab that studies immune responses to infectious diseases and cancer, aiming to develop vaccines and immunotherapies.

The Immune Aging Regulation Lab pursues drug discovery research that returns results to patients and is oriented toward clinical use, centered on immunological studies of infectious diseases and intractable cancers. Using samples from non-human primates and clinical specimens from humans, it uncovers the diverse immune responses seen in each disease. In the future, it aims to lead to the development of new vaccines and immunotherapies. On the lab's website, it is introduced as the “Precision Immunology Project” of the Center for Intractable Diseases and Immunogenomics.

#Immune response #Infectious diseases #Cancer immunotherapy

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感染制御学分野 (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.