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Stem Cell Regulation Lab
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A lab that uses cells made from stem cells to study the efficacy and toxicity of drugs.
AboutAbout the lab
Building drug discovery evaluation systems from stem cells.
The Stem Cell Regulation Lab conducts research to build systems that evaluate the efficacy and toxicity of drugs, using blood cells, hepatocytes, and other cells differentiated from stem cells such as ES cells and iPS cells.
Its aim is to accelerate drug discovery research.
While clarifying the molecular mechanisms of development, the lab applies the information obtained to developing methods for inducing stem cell differentiation and to drug discovery.
On the website of the National Institutes of Biomedical Innovation, Health and Nutrition, the lab is introduced under the name “Cell Models for Drug Discovery Research Project.”
Key terms
- Stem cells
- Cells that can self-renew and differentiate into multiple cell types, giving rise to various kinds of cells. ES cells and iPS cells are also types of stem cells.
- Differentiation induction
- Differentiating stem cells into target cells. It is considered to be the reproduction of processes such as organ formation in the fetal period in a culture dish.
- BBB model
- An evaluation system that reproduces the blood-brain barrier in vitro, using brain vascular endothelial cells made from human iPS cells.
ResearchResearch themes
The lab aims to accelerate drug discovery research by creating new systems that evaluate the efficacy and toxicity of drugs using cells differentiated from stem cells. Its work bridges basic and applied research, from elucidating the molecular mechanisms of development to developing differentiation methods and applying them to drug discovery.
*Illustrative imageControl of stem cell differentiation and applications in drug discovery
The lab regards differentiating stem cells into target cells as reproducing developmental processes, such as organ formation in the fetal period, in a culture dish, and studies the molecular mechanisms of development. It applies the information obtained to developing differentiation methods and to drug discovery.
*Illustrative imageMethods for inducing differentiation into brain vascular endothelial cells
The lab differentiates brain vascular endothelial cells from human iPS cells and develops in vitro blood-brain barrier (BBB) models. Its research covers evaluating the pharmacokinetics of drugs that act on the central nervous system, developing drug delivery system (DDS) technology that actively transports drugs to the brain, and reproducing disease conditions in which the BBB is abnormal.
MembersFaculty
The members of the Stem Cell Regulation Lab consist of a project leader, researchers, visiting researchers, and technical assistants.
- Project LeaderKenji Kawabata
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Ips cells ja” Calvero / Public domain (cropped)
- Control of stem cell differentiation and applications in drug discovery: “Cardiac Stem Cell Differentiation” Jweiss20 / CC BY 4.0 (cropped)
- Methods for inducing differentiation into brain vascular endothelial cells: “Blood-Brain Barrier (NIH BioArt 688)” NIH NIAID Ryan Kissinger / Public domain (cropped)
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