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Faculties at The University of Osaka ›
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Toyomasa Katagiri, Project Leader
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Aiming to eradicate cancer, the Biofunctional Molecule Regulation Lab conducts research to clarify the mechanisms of carcinogenesis through analysis of genome information and to develop new therapeutic drugs. It finds “cancer-specific molecules,” whose expression is elevated only in cancer cells, and aims to develop therapeutic drugs that target only cancer cells. Experiments are mainly done with cancer cell lines, but the lab also places weight on data observed in human cancer clinical specimens. On the lab's website, it is introduced as the “Biofunctional Molecule Regulation Project” of the National Institutes of Biomedical Innovation, Health and Nutrition.
Kazuma Kiyotani, Project Leader
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Keeping in mind 'research that benefits patients' and 'research that can be returned to patients,' the Immunogenomics Lab aims to realize precision medicine, which provides the optimal treatment for each individual patient. Using data centered on genome analysis and immunogenomic analysis, the lab aims to elucidate the causes of diseases, search for biomarkers, and develop new immunotherapies. The lab is also working on developing personalized cancer immunotherapy based on each patient's genomic and gene expression information. The lab's website is the page of the 'Intractable Disease and Immuno-Genomics Research Project' at the National Institutes of Biomedical Innovation, Health and Nutrition.
Masaya Yamaguchi, Project Leader
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The Bacterial Informatics Lab studies the mechanisms by which pathogenic bacteria cause disease. The lab says that clarifying how diseases arise reveals the molecules that should be targeted by drugs, which leads to the development of preventive and therapeutic methods. In addition to infections caused by Streptococcus pneumoniae and Streptococcus pyogenes, the lab studies the human microbiome using genomic information and molecular biology experiments. On the institute's website, the lab is introduced as the 'Bacterial Informatics Project' of the National Institutes of Biomedical Innovation, Health and Nutrition.
藤田 雅史
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Effects of anticancer drugs on cardiac function and thrombus formation
Satoshi Yasuda, Director
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The Division of Cell-Based Therapeutic Products has as its mission building the scientific basis for evaluating the quality, efficacy, and safety of cell-processed products derived from humans or animals, among regenerative medicine products. Aiming to promote the prompt practical use of effective and safe cell-processed products, the division conducts scientific studies based on regulatory science and disseminates information. The division has four sections: Sections 1 to 3 handle cell therapy products, tissue-engineered products, and iPS cell-processed products, and Section 4 handles viral safety. The page registered as the lab website of the Gene and Cellular Medicine Lab is that of the Division of Cell-Based Therapeutic Products at the National Institute of Health Sciences, where the academic advisor, Prof. Yasuda, serves as division head.
井上 貴雄
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The Division of Molecular Target and Gene Therapy Products at the National Institute of Health Sciences conducts regulatory science research that contributes to ensuring the quality, efficacy, and safety of advanced drugs such as gene therapy products, nucleic acid drugs, and molecularly targeted drugs. The development of these drugs has expanded the possibility of treating intractable diseases and disorders that were previously considered incurable. It is also reported that research and development is advancing on diagnostic technologies used to assess disease conditions and evaluate treatment effects, as well as genetic diagnostic technologies for personalized medicine (tailor-made medicine), which provides the care best suited to each individual. The website registered for this lab is that of the Division of Molecular Target and Gene Therapy Products.
石井 明子, Director
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The Division of Biological Chemistry and Biologicals at the National Institute of Health Sciences conducts regulatory science research that helps ensure the quality, efficacy, and safety of biopharmaceuticals. The products studied include novel biopharmaceuticals with new active ingredients and biosimilars (follow-on biologics). Its goal is to develop the evaluation methods needed to manage quality risks and to take the lead in advancing standardization. The introduction of the Biopharmaceutical Sciences Lab is based on the content of this division's website.
阿部 康弘
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Characterization of nanoparticle formulations, bioequivalence evaluation methods
Kenichi Masumura, Director
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The Chemical Safety Assessment Lab collects information on the safety of chemical substances and researches methods for predicting and assessing health effects based on the results of toxicity tests. The lab's website is that of the Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences. For foods, drugs, tap water, cosmetics, household products, and the like to be used safely, it is necessary to set safety standard values for the chemical substances they contain and to manage them appropriately. This research makes it possible to introduce new assessment methods into regulation and to advance the replacement of animal testing with methods that do not use laboratory animals. The lab conducts its research in cooperation with domestic and international organizations such as the Ministry of Health, Labour and Welfare, the WHO, and the OECD.
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