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Faculties at The University of Osaka ›

Hiroshi Hibino, Professor
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The Integrative Pharmacology Lab focuses mainly on the inner ear and pharmacokinetics, studying in detail how the body is built and how it works, and how diseases arise. The lab draws on techniques and knowledge from other fields, including engineering, and uses measurement technologies that it has developed and optimized on its own through medical-engineering collaboration. Using animal models, the lab is committed to measuring local sites in vivo, and combines this with histological, biochemical, and molecular biological analyses. The lab has also begun research on hearing, the brain, and brain diseases.

Kazuhiro Suzuki, Professor
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The Environmental Response Pharmacology Lab aims to clarify, at the cellular and molecular level, how the nervous system regulates immune responses. Using mice, the lab investigates how noradrenaline released from sympathetic nerves affects the movement of lymphocytes. Using molecules involved in lymphocyte migration as clues, the lab is also developing new treatments for autoimmune diseases. The lab's website introduces it under the name "Immune Response Dynamics Lab."

Ryo Kawasaki, Professor
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The Public Health Lab conducts epidemiological research on a wide range of diseases through cohort studies, studies using administrative health data, and clinical database studies. The lab also works on social epidemiology, policy evaluation, and digital health research. In collaboration with universities and research institutions in Japan and abroad, the lab runs various cohort studies and analyzes their data. The lab belongs to the Department of Social Medicine at the Graduate School of Medicine, The University of Osaka.

Hiroshi Matsumoto, Professor
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The lab works in forensic medicine, the only field of medicine that deals with the death of an individual, and centers its research on cause-of-death investigation, starting from the question of why people die. The lab clarifies the mechanisms of sudden deaths that never reach clinical care, deaths caused by the environment such as heatstroke and freezing, and alcohol-related deaths, and studies how to prevent and treat them. Autopsy is not the only way to investigate a cause of death. The lab also uses biochemical tests during autopsy, analysis of drugs and poisons with mass spectrometry instruments, and whole-exome sequencing with next-generation sequencers. Medical students can choose this lab through the Year 3 basic lab placement or the Year 5 lab placement.

Eiryo Kawakami, Professor
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The lab uses artificial intelligence and data science to tackle problems in medicine and healthcare. It aims to draw out new ways of seeing disease by linking diverse medical data, including electronic health records, health checkups, medical images, genetic and omics data, and wearable data. It pursues predicting disease onset and severity, understanding differences between patients, and understanding disease mechanisms at the molecular level as one continuous flow. The lab aims to use AI not merely as a tool but as a foundational technology that changes how medicine and medical research are done.

Kiyoshi Takeda, Professor
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The lab researches how to make it possible to control intractable immune diseases that current medical technology cannot cure. It focuses especially on inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis, studying the intestinal immune system, gut environmental factors such as gut bacteria and dietary components, and the function of the epithelial layer that separates the two. Inflammatory bowel disease is thought to develop when abnormalities of the gut environment overlap with abnormalities of the immune system. The lab welcomes students who take an active rather than passive approach and are passionate about immunology research.

Masaru Ishii, Professor
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The Immune Cell Biology Lab studies how cells of the immune and blood systems move within the body and how they link the functions of organs and tissues. As cells of the immune and blood systems circulate throughout the body, the functional connections among organs and tissues are maintained. When these connections break down, various diseases arise, including lifestyle-related diseases and cancer. The lab observes the inside of bone in living animals using two-photon excitation microscopy, and examines immune cells and other cells by in vivo imaging. The lab is a core department of both the Graduate School of Medicine and the Graduate School of Frontier Biosciences, and can accept graduate students from either.

Takashi Nagasawa, Professor
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The Stem Cell Biology Lab studies the physiology and pathology of the microenvironment (niche) in the bone marrow that maintains and regulates hematopoietic stem cells, which give rise to all blood cells and immune cells. Tissue stem cells are special cells that can generate diverse mature cells and divide repeatedly. They are maintained by adhering to a special microenvironment called the niche. The lab discovered CAR cells, which form the hematopoietic stem cell niche in the bone marrow, and investigates how the niche forms and how it relates to blood, immune, bone, and metabolic diseases, including leukemia. On the lab's website, it is presented under the name "Stem Cell and Immune Development Lab."

Kazuyo Moro, Professor
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The Host Defense Lab focuses on an immune cell called the group 2 innate lymphoid cell (ILC2) and conducts research toward overcoming type 2 immune diseases, including allergy. ILC2s are deeply involved in the pathology of allergy, and they also play a role in expelling parasites. The lab studies everything in a consistent line, from how ILC2s are generated, function, and are suppressed, to how diseases arise and the development of new therapies. The lab has sites at Osaka University and RIKEN, and is presented on the lab's website under the name "Moro Lab."

Yukio Kawahara, Professor
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The Neurogenetics Lab aims to clarify which human diseases are associated with abnormalities in RNA metabolism. The lab focuses on identifying the causes of intractable neurological diseases, including amyotrophic lateral sclerosis (ALS), and on establishing treatments. Students who wish to can learn and conduct research in both molecular biology experiments and bioinformatics for data analysis. The lab is always recruiting master's and doctoral students, and welcomes those who are eager to work on RNA editing and modification, RNA immunity, or ALS.
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