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Environmental Response Pharmacology Lab
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A lab that uncovers the molecular links between the nervous and immune systems, aiming to develop new treatments.
AboutAbout the lab
Uncovering the molecular mechanisms that link the nervous and immune systems, toward next-generation therapeutics
The Environmental Response Pharmacology Lab aims to clarify, at the cellular and molecular level, how the nervous system regulates immune responses.
Using mice, the lab investigates how noradrenaline released from sympathetic nerves affects the movement of lymphocytes.
Using molecules involved in lymphocyte migration as clues, the lab is also developing new treatments for autoimmune diseases.
The lab's website introduces it under the name "Immune Response Dynamics Lab."
Key terms
- Sympathetic nerves
- Together with the parasympathetic nerves, they form the autonomic nervous system and coordinate the functions of organs throughout the body. They also extend branches into lymphoid organs
- Lymphocytes
- A type of immune cell. Using lymph nodes as relay stations, they travel through the body in lymph and blood, watching for invading pathogens
- Autoimmune disease
- A disease in which the immune system attacks the body's own tissues and impairs their function. Rheumatoid arthritis is a typical example
- COMMD3/8 complex
- A protein complex that promotes chemokine receptor signaling. It is important for lymphocyte migration and for mounting immune responses
NewsLab news
A paper by an Assistant Professor and colleagues was published in The Journal of Clinical Investigation
The lab is recruiting graduate students for admission in April 2027
A student won the Best Presentation Award at the 9th Annual Meeting of the Japanese Society for Immunodeficiency and Autoinflammatory Diseases
An undergraduate medical student won the Best Presentation Award at the research presentation meeting for students assigned to basic medical science labs
ResearchResearch themes
The lab's goal is to clarify, at the cellular and molecular level, how input from the nervous system affects the immune system. At the same time, it is developing new treatments for autoimmune diseases that target the movement of lymphocytes in the body.
*Illustrative imageHow the nervous system regulates immune responses
Using mice, the lab found that noradrenaline released by sympathetic nerves retains lymphocytes in lymph nodes. It has also shown that this mechanism produces the diurnal variation in the strength of immune responses over the course of a day.
*Illustrative imageTreatments that target lymphocyte migration
The lab showed that the COMMD3/8 complex promotes chemokine receptor signaling and is important for lymphocyte migration and immune responses. Celastrol, a compound that inhibits this function, suppressed the progression of arthritis in a mouse model of rheumatoid arthritis.
MembersFaculty
The members of the Environmental Response Pharmacology Lab consist of faculty, visiting faculty, concurrent faculty, research students, PhD and master's students, technical staff, and administrative assistants.As of 2026
- ProfessorKazuhiro Suzuki
- Assistant ProfessorTaichiro Shirai
- Assistant ProfessorSatomi Komori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microscopy in bloom” Saraifveiga / CC BY 4.0 (cropped)
- How the nervous system regulates immune responses: “Lymph Node of Person Without HIV” NIAID / CC BY 2.0 (cropped)
- Treatments that target lymphocyte migration: “Primary immune response 1” Sciencia58 an the makers of the single images Domdomegg, [1], Fæ, Petr94, Manu5 / CC BY-SA 4.0 (cropped)
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