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Host Defense Lab
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The lab investigates the mechanisms of allergy and other diseases through the immune cell ILC2.
AboutAbout the lab
Aiming for research that will change history
The Host Defense Lab focuses on an immune cell called the group 2 innate lymphoid cell (ILC2) and conducts research toward overcoming type 2 immune diseases, including allergy.
ILC2s are deeply involved in the pathology of allergy, and they also play a role in expelling parasites.
The lab studies everything in a consistent line, from how ILC2s are generated, function, and are suppressed, to how diseases arise and the development of new therapies.
The lab has sites at Osaka University and RIKEN, and is presented on the lab's website under the name "Moro Lab."
Key terms
- ILC2
- An innate immune cell that is activated without recognizing antigens and produces large amounts of type 2 cytokines. It is found in various tissues throughout the body
- Cytokine
- A protein that mediates communication between immune cells. Examples include IL-25 and IL-33
- Transcription factor
- A protein that regulates gene activity. The lab found that GATA3 is important for ILC2 differentiation
NewsLab news
Admissions policy and lab tours announced for prospective master's and doctoral students
A member won a Poster Award at the 25th Immunology Summer School 2024 in Shonan
A School of Medicine student won a Poster Award at JCS2024
ResearchResearch themes
ILC2s are immune cells that respond strongly to cytokines such as IL-25 and IL-33 released by damaged epithelial cells, and produce large amounts of type 2 cytokines. The lab investigates ILC2 function from the basics, aiming to connect this to an understanding of various diseases, including allergies and infections.
*Illustrative imageMechanisms of ILC2 differentiation and activation
The lab investigates how ILC2s differentiate in peripheral tissues, how they are activated by stimuli such as cytokines, and how they are suppressed. Having found that the transcription factor GATA3 is important for differentiation, the lab aims to clarify the whole picture of differentiation.
*Illustrative imageUnderstanding allergic disease and developing treatments
The lab studies the mechanism of allergy in which ILC2s respond after house dust mite antigens or pollen damage epithelial cells. It has also clarified the role of ILC2s in severe asthma that responds poorly to steroids, and aims to establish new therapies that target ILC2s.
*Illustrative imageRoles in other immune diseases and infections
In metabolic diseases such as obesity and diabetes, inflammatory bowel disease, and autoimmune diseases, the lab investigates the mechanisms of disease and whether ILC2s could be therapeutic targets. It also studies the mechanisms of ILC2 defense responses in parasitic, fungal, and influenza infections.
MembersFaculty
- ProfessorKazuyo Moro
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “House Dust Mite” Employee of US Government / Public domain (cropped)
- Mechanisms of ILC2 differentiation and activation: “SEM Lymphocyte” Unknown photographer/artist (False color modifications made by myself--DO11.10) / Public domain (cropped)
- Understanding allergic disease and developing treatments: “Allergies?” Nicholas Wedige / Public domain (cropped)
- Roles in other immune diseases and infections: “Inflammatory Bowel Disease MTK” WolfpackBME / CC BY-SA 4.0 (cropped)
- Related lab (Neurology Lab): “Neuron (100x magnification)” Ns takes photos / CC BY 4.0 (cropped)
- Related lab (Endocrinology and Metabolism Lab): “Inzulínová pera” Mr Hyde at Czech Wikipedia (Original text: moje foto) / Public domain (cropped)
- Related lab (Dermatology Lab): “Dermatology - Skin -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Environmental Response Pharmacology Lab): “Microscopy in bloom” Saraifveiga / CC BY 4.0 (cropped)
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