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63 labs · 0 student voices
Other departments in School of Medicine ›Faculties at The University of Osaka ›
Makoto Sato, Professor
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The Neural Function and Morphology Lab studies how the neocortex, which exists only in higher animals, is formed. Psychiatric disorders such as developmental disorders and schizophrenia are also thought to have their causes or predisposing factors in minor malformations that occur when the brain is formed. Using mice, the lab studies the migration of neurons and the formation of circuits of nerve fibers extending from the cerebral cortex. Members from different undergraduate faculties, such as medicine, science, and agriculture, work together on research.
Akihiro Harada, Professor
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The Cell Biology Lab aims to elucidate the mechanisms of polarized transport, which is important for protein secretion in cells and for the formation and maintenance of cell polarity. The lab investigates the structure and function of the Golgi apparatus using super-resolution microscopy and electron microscopy. The lab also generates knockout mice lacking specific genes and analyzes how transport changes in cells and in whole organisms.
Toshihide Yamashita, Professor
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The Molecular Neuroscience Lab conducts basic research and developmental research that contribute to overcoming the lasting impairments of the nervous system caused by cerebrovascular disease and by trauma to the brain and spinal cord. In the brain and spinal cord, neurons work by forming networks, and when these networks are damaged, recovery is extremely rare. Believing that central nervous system disorders can be treated if the lost networks can be repaired, the lab aims to establish new neural regeneration therapies. At the same time, the lab seeks to study the dynamics of the process by which neural circuits are repaired through an integrated approach.
Shigeru Kitazawa, Professor
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The Brain Physiology Lab studies a wide range of brain functions, including perception, movement, cognition, and communication. Under the motto of "brain science that you can experience," the lab works on topics such as the mechanism by which the world does not appear to move even when the eyes move, the sense of mental time, and the mechanisms of motor learning. In addition to behavioral experiments and brain activity measurements in humans, the lab also examines brain activity in monkeys. On the lab's website, it is introduced under the name "Dynamic Brain Network Lab."
Yoshifumi Okochi, Associate Professor
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The Integrative Physiology Lab studies ion channels, the proteins responsible for electrical signals in living organisms, from their microscopic structure and function to their physiological roles in the whole organism. The lab takes approaches including molecular biology, knockout mice, electrophysiology, imaging, and structural biology. The lab discovered two proteins with voltage sensors, VSP and VSOP/Hv1, and is investigating how they work and what roles they play in the body.
Seiji Takashima, Professor
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The Medical Biochemistry Lab studies how life processes work and how diseases arise, using the functions of proteins as clues. The lab prioritizes exploratory research, which first discovers new biological phenomena at the molecular level, and connects it to its own systems for analyzing physiological function. The ultimate goal is to understand disease pathology and develop disease treatments. The main target diseases are cardiovascular diseases such as heart failure and ischemic heart disease. The lab believes that collaboration and cooperation with researchers and institutions across fields, not only within cardiovascular research, is essential.
Noriyuki Tsumaki, Professor
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The Tissue Biochemistry Lab studies how cartilage, the basis of the skeleton, forms, and the diseases that affect cartilage. Cartilage includes articular cartilage and growth plate cartilage. Abnormalities of articular cartilage cause joint movement disorders, and abnormalities of growth plate cartilage cause skeletal growth disorders. Using techniques of biochemistry, molecular biology, and histology, the lab investigates the mechanisms that regulate cartilage formation and differentiation, and attempts to elucidate the pathology of cartilage diseases. The lab also works on new regenerative therapy for cartilage using iPS cell technology, as well as on drug discovery.
Takeshi Bamba, Professor
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The Systems Metabolism Lab (Bamba Lab) conducts research on technologies for analyzing the metabolome, the totality of metabolites, and on the field of study known as metabolomics. Using chromatography and mass spectrometry, the lab develops analytical methods that measure intracellular metabolic information with high sensitivity and quantitative accuracy. With the methods it develops, the lab investigates the relationship between disease and metabolism from basic to applied research, and also aims at integrated analysis with other omics. Through thorough on-the-job training, the lab aims to develop professional analytical chemists who can be active around the world.
Eiichi Morii, Professor
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The Disease Pathology Lab works on both pathological diagnosis of specimens at the University Hospital and pathology research. For the diseases encountered in daily diagnosis, the lab imagines the mechanisms behind what can be seen and conducts research to test them. The lab focuses on tumor heterogeneity: tumor cells that should be a single clone have different properties from cell to cell. The lab also works on methods for observing pathological tissue with new technologies.
Daichi Inoue, Professor
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The Cancer Pathology Lab investigates the mechanisms of blood cancers such as myelodysplastic syndromes and acute myeloid leukemia, and extends its research to solid cancers in general. The lab seeks to understand the differences between normal stem cells and cancer stem cells, and aims at therapeutic applications that build on the vulnerabilities of cancer revealed by those differences. From the perspectives of genomic mutations, post-transcriptional regulation, chromatin regulation, metabolic reprogramming, and cell death, the lab tackles cancer from both basic and clinical sides.
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