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Stem Cell Biology Lab
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The lab explores the bone marrow niche that supports hematopoietic stem cells.
AboutAbout the lab
Decoding the bone marrow environment that supports stem cells.
The Stem Cell Biology Lab studies the physiology and pathology of the microenvironment (niche) in the bone marrow that maintains and regulates hematopoietic stem cells, which give rise to all blood cells and immune cells.
Tissue stem cells are special cells that can generate diverse mature cells and divide repeatedly. They are maintained by adhering to a special microenvironment called the niche.
The lab discovered CAR cells, which form the hematopoietic stem cell niche in the bone marrow, and investigates how the niche forms and how it relates to blood, immune, bone, and metabolic diseases, including leukemia.
On the lab's website, it is presented under the name "Stem Cell and Immune Development Lab."
Key terms
- Niche
- A special microenvironment to which stem cells adhere and are maintained, and in which their number, proliferation, and differentiation are regulated
- Hematopoietic stem cell
- A tissue stem cell that gives rise to all blood cells and immune cells in the bone marrow
- CAR cell
- A bone marrow cell that forms the hematopoietic stem cell niche. It is also a mesenchymal stem cell that supplies osteoblasts and adipocytes
ResearchResearch themes
The lab aims to clarify the physiology and pathology of the microenvironment (niche) that maintains and regulates hematopoietic stem cells and immune cells in the bone marrow. It studies, at the cellular and molecular levels, how the niche forms and how it relates to disease.
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MembersFaculty
The members of the Stem Cell Biology Lab consist of faculty and an administrative assistant (secretary).
- ProfessorTakashi Nagasawa
- Associate ProfessorYoshiki Omatsu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “MACD187 Bone-marrow-and-blood-cells” 2441050indupranavpasupula / CC BY-SA 4.0 (cropped)
- Formation and function of the hematopoietic stem cell niche: “Leukemia bone marrow” HildeErling / CC BY-SA 3.0 (cropped)
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- Related lab (組織生化学): “Stem Cell Research ( )” The U.S. Food and Drug Administration / Public domain (cropped)
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