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Immune Regulation Lab
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A lab that approaches the pathology of intractable immune diseases through intestinal immunity and the gut environment.
AboutAbout the lab
Elucidating the causes and pathology of intractable immune diseases
The lab researches how to make it possible to control intractable immune diseases that current medical technology cannot cure.
It focuses especially on inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis, studying the intestinal immune system, gut environmental factors such as gut bacteria and dietary components, and the function of the epithelial layer that separates the two.
Inflammatory bowel disease is thought to develop when abnormalities of the gut environment overlap with abnormalities of the immune system.
The lab welcomes students who take an active rather than passive approach and are passionate about immunology research.
Key terms
- Inflammatory bowel disease
- An intractable disease, represented by Crohn’s disease and ulcerative colitis, in which the intestine repeatedly becomes inflamed. It is one of the designated intractable diseases in Japan.
- Gut environmental factors
- Things that shape the environment inside the intestine, such as gut bacteria and dietary components. This lab studies their effects on intestinal immunity.
- Epithelial layer
- The layer of epithelial cells lining the inside of the intestine. It forms the boundary that separates the immune system from gut environmental factors.
NewsLab news
Associate Professor Murakami’s review article was published in Int Immunol
A paper by Associate Professor Kayama and colleagues was published in Int Immunol
Associate Professor Murakami’s review article was published in Immunol Cell Biol
An undergraduate student received the Yamamura Award upon graduation
Associate Professor Kayama’s review article was published
ResearchResearch themes
Aiming to make it possible to control intractable immune diseases that current medicine cannot cure, the lab studies inflammatory bowel diseases, represented by Crohn’s disease and ulcerative colitis. It analyzes them from three aspects: the immune system, gut environmental factors, and the function of the epithelial layer that separates the two.
*Illustrative imageAnalyzing immune cells in the intestine
The lab has studied innate immune cells in the intestinal mucosa and discovered CD70-positive dendritic cells and regulatory myeloid cells that are specific to the intestine. It analyzes how the activity of these cells is controlled and how abnormalities in them relate to intestinal inflammation.
*Illustrative imageEffects of gut environmental factors on immunity
Using germ-free mice and mice fed diets of various compositions, the lab analyzes how gut environmental factors such as gut bacteria and dietary components regulate the immune system of the intestinal mucosa. It has found that gut bacteria-derived ATP, diet-derived vitamin B9, and bile acids are deeply involved.
*Illustrative imageBarrier function of the intestinal epithelial layer
Using various knockout mice, the lab analyzes how the epithelial cell layer, which forms the boundary between the immune system and gut environmental factors, maintains the barrier. It aims to clarify how abnormalities in this layer cause intestinal inflammation.
MembersFaculty
The members of the Immune Regulation Lab consist of faculty, project researchers, visiting faculty, project technical staff, administrative staff, doctoral, master’s, and undergraduate students, and research students.As of 2026
- ProfessorKiyoshi Takeda
- Associate ProfessorHisako Kayama
- Associate ProfessorDiez Diego
- Associate ProfessorMari Murakami
- Assistant ProfessorRyu Okumura
- Assistant ProfessorEri Inogashira
- Assistant ProfessorTakaki Ito
- Project Assistant ProfessorYuji Yamamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Intestinal bacteria culture test tube” Fumikas Sagisavas / CC0 (cropped)
- Analyzing immune cells in the intestine: “Intestinal Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Effects of gut environmental factors on immunity: “Visitors to NIH Germ Free Laboratory ( )” NIH History Office from Bethesda / Public domain (cropped)
- Barrier function of the intestinal epithelial layer: “Glandular epithelium of small intestine (crypts of Lieberkühn)” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Dermatology Lab): “Dermatology - Skin -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Neurology Lab): “Neuron (100x magnification)” Ns takes photos / CC BY 4.0 (cropped)
- Related lab (Urology Lab): “Workingelement” Ramonduran / CC BY 3.0 (cropped)
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