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702 labs · 51 student voices
Shinji Nakaoka, Professor
0 student voices
The Mathematical Biology Lab brings the methods of mathematical science and data analysis into biology in order to understand life phenomena. The lab uses mathematical models and simulations to test what cannot be understood from experimental and observational data alone. Themes are wide-ranging, including the ecosystems of gut and soil microbiota, analysis of medical data, and bioinformatics using comprehensive gene sequence data. Mathematics, informatics, and molecular biology are mainly involved, but the field you studied before joining the lab does not matter when you are assigned.
Hiroshi Hino, Professor
0 student voices
The Advanced Biological Regulation Science Lab studies the mechanisms of life and new medicines through the chemistry of sugars and glycans. Glycans display various patterns on the outside of cells, and, like blood types and serotypes, they serve as markers that represent the characteristics of an organism. Building on its own synthesis and analysis technologies, the lab develops "glycotyping," a technology that quickly captures the characteristics of glycan shapes. The lab aims to use the resulting technologies in materials science and life science, and also to connect them to the development of next-generation drugs.
Kenji Monde, Professor
0 student voices
The Chemical Biology Lab studies biomolecules such as nucleic acids, proteins, glycans, and lipids, aiming to understand them at the atomic level. In particular, the lab focuses on the difference between right-handed and left-handed forms of molecules (chirality) and is developing new analytical methods. It applies methods such as vibrational circular dichroism (VCD) to glycans and lipids, and examines the relationship between structure and biological function. The lab also works on developing enzyme inhibitors for lipid-related diseases such as obesity, Alzheimer's disease, atopic dermatitis, and cancer.
Hiroaki Adachi, Associate Professor
0 student voices
The lab studies how plants recognize pathogenic microorganisms and how they defend themselves. Plants have sensors called NLR immune receptors, which detect pathogen invasion and trigger immunity. Combining genome analysis, AI, and protein structure analysis, the lab predicts how receptors function from genome information and then tests those predictions. Pathogens, for their part, remodel plant tissues to settle in. The lab also makes these strategies visible under the microscope.
Ryota Uehara, Associate Professor
0 student voices
The lab studies cell division and changes in the number of genomes a cell carries (ploidy). Accurate cell division is essential for sustaining and passing on life, yet how a cell divides its contents equally and splits itself in two is still not understood. When the control of division goes wrong, the number of chromosomes changes and the properties of the cell change dramatically, which can also cause serious diseases such as cancer. Combining techniques for examining and manipulating cells, the lab aims to uncover, at the molecular level, the structure and workings of the "cellular apparatus" that supports division.
Takashi Kikukawa, Associate Professor
0 student voices
The lab studies the mechanisms of proteins that function when they receive light. The main research subject is microbial rhodopsin, a photoreceptor protein found in microorganisms. Using spectroscopy and electrochemical measurements, the lab follows how the shape of the protein changes step by step after light is applied. Based on the mechanisms uncovered, the lab also aims to give proteins new functions.
Akira Kitamura, Associate Professor
0 student voices
The Cell and Molecular Functional Science Lab studies how proteins move and assemble inside cells. Proteins work after folding correctly, but when folding fails they can clump together and form aggregates. Because these aggregates are linked to neurodegenerative diseases, the lab investigates how they form and how they affect cells. Taking advantage of the fact that light does little harm to living organisms, the lab is pioneering methods to measure molecules inside living cells.
Kiminori Nakamura, Professor
0 student voices
The Innate Immunity Lab studies how innate immunity works in the mucosa of the gut. Paneth cells in the small intestine, when stimulated by infection, release antimicrobial peptides that kill microbes. The lab investigates how these antimicrobial peptides work and how they maintain the relationship with microbes in the gut. It aims to clarify the causes and pathology of infectious diseases and intractable immune diseases from the perspective of innate immunity.
Xiang Li, Professor
0 student voices
The Soft Matter Structural Physics Lab studies soft materials such as gels and polymer solutions. Even the bodies of living things, seen at the nano scale, are made of countless strands (polymers) packed together. The lab examines the nanostructure inside materials from how light, X-rays, or neutrons scatter when they hit them. Combining rheology and spectroscopy as well, it works to clarify the mechanisms behind the observed physical properties.
Koichi Fujiwara, Professor
0 student voices
The Biological Data Science Lab studies methods for building useful AI from small amounts of data (small data). Rare events and data that are costly to collect cannot be obtained in large quantities. The lab therefore develops machine learning algorithms and mathematical models that also incorporate the experience and knowledge of experts. Working across two universities, Hokkaido University and Nara Institute of Science and Technology, the lab applies this research to the development of medical AI, medical devices, and production systems.
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