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Advanced Biological Regulation Science Lab
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The lab reads the shapes of glycans and applies them to the development of new medicines.
AboutAbout the lab
Reading the shapes of sugars to create medicines.
The Advanced Biological Regulation Science Lab studies the mechanisms of life and new medicines through the chemistry of sugars and glycans.
Glycans display various patterns on the outside of cells, and, like blood types and serotypes, they serve as markers that represent the characteristics of an organism.
Building on its own synthesis and analysis technologies, the lab develops "glycotyping," a technology that quickly captures the characteristics of glycan shapes.
The lab aims to use the resulting technologies in materials science and life science, and also to connect them to the development of next-generation drugs.
Key terms
- Glycan
- A chain of many sugars linked together. Found on the cell surface, it serves as a marker for recognizing cells
- Glycotyping
- A technology that reads the characteristics of glycan shapes all at once, using methods such as mass spectrometry
- Epitope
- The part of an antigen, such as a protein, that serves as a marker to which an antibody binds
NewsLab news
A paper on Antibody Glycotyping was accepted by LabMed
A student received a presentation award at the 55th Naito Conference
A student received a presentation award at the International Conference on Interdisciplinary Approach in Life Sciences for Translational Research
A student received a Special Award at the 38th Advanced Technology Award for Pioneering Originality
A student received an Excellent Presentation Award at the 98th General Meeting of the Japanese Society for Bacteriology
ResearchResearch themes
Based on its carbohydrate synthesis and analysis technologies, the lab continually renews those technologies themselves. It pursues research that uses the resulting technologies in materials science and life science.
*Illustrative imageGlycotyping
The lab is developing "glycotyping," a technology that uses mass spectrometry to quickly capture the characteristics of glycan shapes. Like blood types and serotypes, it aims to grasp the characteristics of an organism from its sugar types.
*Illustrative imageMaking Glycoconjugates
The lab is developing methods to synthesize, easily and comprehensively, glycoconjugates such as glycopeptides and glycolipids, which were previously difficult to prepare. It also designs and synthesizes inhibitors of enzymes that change glycan structures, and examines how they work.
*Illustrative imageDynamic Epitope Theory
The lab found that differences in glycan structure greatly change the three-dimensional structure of a protein antigen. Based on this "dynamic epitope theory," it is advancing research and development of antibody drugs that attack disease-specific regions, in collaboration between industry and academia.
MembersFaculty
The members of the Advanced Biological Regulation Science Lab include faculty, postdoctoral researchers, laboratory assistants, joint researchers, secretaries, and students in the doctoral program, the master's program, and the undergraduate program.As of 2023
- ProfessorHiroshi Hino
- Project ProfessorShin-Ichiro Nishimura
- Assistant ProfessorYasuhiro Yokoi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sugar crystals under a microscope 1” Gustamons / CC0 (cropped)
- Glycotyping: “A-blood group” A-tom 81 / CC BY 3.0 (cropped)
- Making Glycoconjugates: “1abn” PDBsum staff at the European Bioinformatics Institute / Public domain (cropped)
- Dynamic Epitope Theory: “AngeloftheWest” Julian Voss-Andreae (Julianva at en.wikipedia) / CC BY-SA 3.0 (cropped)
- Related lab (Ogawa Lab (Systems Neurobiology)): “African.field.cricket.arp” Arpingstone / Public domain (cropped)
- Related lab (Biomolecular Device Lab): “Au nanoparticles” Nikonianman / CC BY-SA 4.0 (cropped)
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