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702 labs · 51 student voices

Kyoko Miwa, Professor
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The Miwa Lab studies, at the molecular level, how plants respond to the soil environment in order to live. Through evolution, plants have developed mechanisms to selectively take up the inorganic elements they need from the soil and to exclude elements that are toxic. The lab focuses in particular on boron, one of the essential elements, and investigates how plants sense nutrient deficiency and excess and how they regulate transport and metabolism accordingly. Based on these findings, the lab aims to create plants that can grow even in nutrient-poor soil.

Chiaki Hori, Professor
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The Hori Lab studies the struggle over carbon between trees and fungi in forests. Trees defend themselves against microbial attack with sturdy cell walls and antimicrobial compounds, but fungi such as mushrooms have evolved the ability to break these down. Using fungi that the lab isolates from the environment itself, together with their genetic information, the lab searches for the molecular mechanisms of decomposition and for new enzymes. The lab also pursues applied research that links its basic findings to the use of degrading enzymes and to microbial control for trees.

Kenji Washio, Assistant Professor
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The lab seeks to understand, at the gene level, the mechanisms of living organisms that protect the global environment. It aims to develop new methods of environmental management that make use of the diverse biological functions found in nature. Assistant Professor Washio studies how plant hormones support growth in plants such as rice.

Chikako Nagasato, Professor
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The Cell Culture Engineering Lab studies brown algae, including kelp and wakame, using the methods of cell biology and molecular biology. Brown algae have complex alternation of generations and reproductive modes, and they are the largest multicellular photosynthetic organisms living in water. The lab investigates how the multicellular body is built and maintained, by looking at how cells divide and how cells are connected to one another. To help sustain seaweed resources, the lab also explores conditions that promote maturation and growth by taking the life cycle through to completion.

Masahiro Nakaoka, Professor
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Akkeshi Marine Station is located on Akkeshi Bay in eastern Hokkaido, and its research centers on marine ecology and biological oceanography. In front of the station lies a sea influenced by the cold Oyashio Current, along with Lake Akkeshi where eelgrass grows in dense stands, as well as wetlands, rivers, and forests. Based on field observations, the lab studies the biodiversity of eelgrass beds and kelp forests, the growth of phytoplankton, and more. Founded in 1931, it is a marine station that focuses mainly on cold-current organisms, where researchers and students from Japan and abroad stay to carry out research and training.

Norishige Yotsukura, Professor
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The Kelp Lab studies the diversity of plants of the order Laminariales (kelps) and their origins. The coasts of the northwest Pacific are among the most kelp-diverse regions in the world. Using molecular biology methods, the lab investigates where Japanese kelps, which include many endemic species, came from and how they expanded their distributions. To prepare for changes in growth environments, the lab identifies the genetic characteristics of various species, and also works on conserving genetic resources and breeding highly productive industrial species. The lab is located in an annex of the Field Science Center for Northern Biosphere on the Sapporo Campus, and conducts its research using the Oshoro Marine Station in Otaru.

Toyoyuki Ose, Professor
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The Structural Biochemistry Lab views life phenomena as a collection of chemical reactions and studies the reactions and interactions carried out by proteins. Its foundation is structural biology: examining the three-dimensional structures of biological macromolecules, and tracing how molecules interact and how enzymes convert substances. The phenomena it covers include the battle between the immune system and viruses, carcinogenesis and signal transduction pathways, unusual enzymatic reactions, and phenomena in which the positions of hydrogen atoms are key. By combining X-ray crystallography, neutron crystallography, electron microscopy, and NMR, the lab aims to connect the reactions carried out by proteins with life phenomena inside cells.

Tomoyasu Aizawa, Professor
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The Protein Science Lab studies how proteins form three-dimensional structures and function. Even though the blueprint can be read from the genome, much remains unknown about the path from that blueprint to the formation of the correct shape and the exertion of function. Using genetic engineering techniques for mass production and NMR methods that can examine the structure and motion of molecules, the lab works with proteins from a wide range of organisms, from microbes and insects to humans. With the goal of freely controlling three-dimensional structure and function, the lab also collaborates with researchers across a wide range of fields to advance applications in medicine and industry.

Takayuki Nonoyama, Associate Professor
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The Fusion Soft Matter Lab studies "soft matter": soft substances such as jelly and rubber. Soft matter has properties of both solids and liquids, and responds sensitively to stimuli and changes in its environment. Soft matter that is compatible with living tissue is attracting attention as a material for medicine and healthcare, including artificial tissue, regenerative medicine, and flexible sensors. The lab also uses natural polymers and biominerals in materials design, and works on creating materials that make use of the land and sea resources of Hokkaido.

Takayuki Kurokawa, Professor
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The Transformative Soft Matter Lab researches the creation of functional polymer hydrogels. The lab repeats a cycle: investigating why the gels it makes have their functions, then using that knowledge to design the next gel. Along the way, technologies related to biomaterials and new ways of measuring physical properties have emerged. Through gels, students can learn from fundamentals to applications, such as understanding the friction and fatigue of tough double-network gels and creating gels for use in medical treatment.
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