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19 labs · 0 student voices
Faculties at Hokkaido University ›
Akio Kihara, Professor
0 student voices
The Biochemistry Lab studies the functions of the diverse lipids in the body. Rather than their well-known roles as energy sources and building materials for biological membranes, the lab focuses on the "barrier function" that keeps substances from passing in and out at the body's surface. It investigates how ceramides in the stratum corneum of the skin, and meibum lipids that form the oil layer of tears, are produced and how they function. Abnormalities in these lipid barriers lead to conditions such as ichthyosis, atopic dermatitis, and dry eye.
Shinichi Nakagawa, Professor
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The RNA Biology Lab studies genes in the genome whose functions are still unknown. Its central focus is long non-coding RNAs (lncRNAs), which do not make proteins, especially those that accumulate abundantly in the cell nucleus. The lab creates mice and medaka in which a gene has been knocked out and examines what changes appear in their bodies and behavior. It also conducts research that uses chemical compounds to probe splicing, the process that cuts and joins RNA, and studies social behavior in medaka.
Shunsuke Kimura, Professor
0 student voices
The Health Chemistry Lab studies the functions of the epithelial cells that cover mucosal surfaces such as those of the intestine and airways. The mucosal epithelium is a barrier that keeps out foreign substances and bacteria. It is also a gateway that senses information from the outside and selectively takes in the substances the body needs. Among these cells, the lab focuses on M cells, which take up foreign substances in the intestine and activate the immune system. Using mouse and human organoids, the lab investigates how M cells form and what roles they play, with the aim of developing mucosal vaccines.
Katsumi Maenaka, Professor
0 student voices
The Biomolecular Function Lab studies the structures and functions of proteins involved in immunity and infection. Immune cells use receptors on their surface to recognize cancer cells and virus-infected cells and eliminate them. The lab investigates these mechanisms down to the atomic level using methods such as cryo-electron microscopy, and applies the results to rational drug design and the development of biopharmaceuticals. The lab's work ranges from analyzing the three-dimensional structures of receptor and antigen proteins to administration experiments in animal models of disease.
Toshiyuki Wakimoto, Professor
0 student voices
The Natural Products Chemistry Lab studies natural products, the compounds that living organisms produce in order to live. Natural products are already used as pharmaceuticals and research reagents, but much remains unknown, such as microorganisms that are difficult to culture and the pharmacological actions of crude drugs. The lab searches for bioactive substances in marine organisms such as sponges and ascidians, as well as in crude drugs and foods, and investigates their structures and how they are produced inside living organisms. The lab aims to apply the principles of nature to drug development.
Yoshihiro Sato, Professor
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The Precision Synthetic Chemistry Lab studies the development of new chemical reactions based on organometallic chemistry. Using metals such as nickel and palladium, the lab creates reactions useful for synthesizing drugs and natural products. The reactions it discovers are applied to the synthesis of biologically active compounds and pharmaceutical precursors. The lab also focuses on developing environmentally friendly organic synthesis reactions and catalytic processes.
長友 優典, Professor
0 student voices
The Natural Product Synthesis Lab studies the synthesis of natural organic compounds (natural products) made by plants and microorganisms. Natural products have supported people's lives as substances useful in medicines, agrochemicals, fragrances, and more. The lab works on developing new synthetic strategies to assemble complex natural products with strong biological activity by concise methods. The lab was launched in November 2023 through the merger of the Pharmaceutical Manufacturing Chemistry Lab and the Organic Chemistry for Drug Discovery Lab.
Masabumi Minami, Professor
0 student voices
The Pharmacology Lab studies how emotions such as pleasure and displeasure arise in the brain. Using methods such as behavioral pharmacology, electrophysiology, optogenetics, and optical imaging, the lab investigates neural activity involved in emotion. It aims to clarify the mechanisms of psychiatric disorders caused by abnormal emotion and to lead to the creation of therapeutic drugs. Through seminars and study groups, the lab lets students learn neuroscience from the basics.
Yuma Yamada, Professor
0 student voices
The Drug Molecular Design Lab studies nanocapsules that deliver drugs to targeted sites inside the body and inside cells. The cargo includes not only small-molecule drugs but also proteins such as antibodies and nucleic acids such as siRNA and genes. The lab aims to develop gene and nucleic acid therapies, drugs that target organelles such as mitochondria, and vaccines.
Hideyoshi Harashima, Project Professor
0 student voices
The Future Pharmaceutics Lab studies new drug delivery systems (DDS) that target the blood vessels in diseased areas to deliver drugs. It works on technology that targets diseased blood vessels in cancer, fat, and the brain to deliver next-generation nucleic acid therapeutics. The lab collaborates closely with the Drug Molecular Design Lab, and also works with the Faculty of Dental Medicine, the Faculty of Engineering, and Hokkaido University Hospital. Students in this lab conduct their research while enrolled in the Drug Molecular Design Lab.
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