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Mathematical Biology Lab
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A lab that deciphers the mechanisms of life phenomena using mathematics and data.

AboutAbout the lab
Understanding life phenomena through mathematics
The Mathematical Biology Lab brings the methods of mathematical science and data analysis into biology in order to understand life phenomena.
The lab uses mathematical models and simulations to test what cannot be understood from experimental and observational data alone.
Themes are wide-ranging, including the ecosystems of gut and soil microbiota, analysis of medical data, and bioinformatics using comprehensive gene sequence data.
Mathematics, informatics, and molecular biology are mainly involved, but the field you studied before joining the lab does not matter when you are assigned.
Key terms
- Mathematical model
- A representation of how a phenomenon works using mathematical equations. By changing conditions and calculating, one can examine future behavior
- Microbiota
- A collection of many kinds of microorganisms living together, such as in the gut or in soil
- Bioinformatics
- A field that uses computers to analyze large amounts of biological data, such as gene sequences
NewsLab news
View More ↗ResearchResearch themes
Research centers on mathematical modeling of life phenomena and the development and application of data analysis methods. Through interdisciplinary research, the lab approaches life phenomena from both fundamental and applied sides.
*Illustrative imageReading microbial communities through mathematics
Communities of cells and microbes change through complex interactions among their components, such as bacteria and viruses. The lab expresses the rules of these interactions in mathematical models, and reconstructs how the dynamics of a community arise in order to understand them.
*Illustrative imageExploring mechanisms from data
To grasp the entities that drive changes in microbial communities, the lab analyzes them with data science methods. Using environmental metagenomic data, it aims to identify the rules linking the loss of gut microbiota diversity to the onset of disease.
*Illustrative imageMathematical modeling of evolution
Using mathematical models, the lab examines which kinds of evolution are likely to occur and which are unlikely. It works on genome analysis of wild organisms, speciation theory, and prediction of infectious disease dynamics.
MembersFaculty
The members of the Mathematical Biology Lab consist of faculty, visiting faculty, postdoctoral researchers, doctoral, master's, and undergraduate students, research students, and staff.
- ProfessorShinji Nakaoka
- Assistant ProfessorRyo Yamaguchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ba model 1000nodes” Keiono / CC BY 3.0 (cropped)
- Reading microbial communities through mathematics: “Complex network n25 WS model” user:Sazaedo (ja:user:猪山人) / Public domain (cropped)
- Exploring mechanisms from data: “E. coli Bacteria ( )” NIAID / CC BY 2.0 (cropped)
- Mathematical modeling of evolution: “Female Galápagos medium ground finch” Charles J. Sharp / CC BY-SA 3.0 (cropped)
- Related lab (Reproductive and Developmental Biology Group (Mizushima)): “1 week old Japanese quail chicks 04” BrokenSphere / CC BY-SA 3.0 (cropped)
- Related lab (Soft Matter Structural Physics Lab): “Hidrogela egoera solidoan” Lialore / CC BY-SA 4.0 (cropped)
- Related lab (Structural Biochemistry Lab): “Lysozyme Protein Crystal in Hanging-Drop Crystallization” Rohit Sharma / CC BY 4.0 (cropped)
- Related lab (Transformative Soft Matter Lab): “Superabsorber Hydrogel KSG 2906 pK” Petra Klawikowski / CC BY-SA 3.0 (cropped)
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