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702 labs · 51 student voices
Atsushi Kimura, Professor
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The Kimura-Fujimori Lab studies the functions of the mammalian genome, especially how gene expression is regulated. Using mouse testis, ovary, and placenta, the lab investigates how genes are activated when sperm and eggs are formed. The key players are long noncoding RNAs, which function without being made into proteins, and DNA sequences that serve two roles. When necessary, the lab generates transgenic mice to confirm the functions of genes.
Asato Kuroiwa, Professor
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The Kuroiwa-Chikami-Yang Lab studies how males and females are determined in animals. Using spiny rats (Tokudaia), a group endemic to Japan that lacks a Y chromosome, the lab investigates the mechanisms of sex determination and the evolution of sex chromosomes. In birds, the lab uses chickens and Japanese quail to clarify the molecular basis of how sex is determined. The lab also studies the evolutionary history of sex determination in insects and reads the diversity encoded in primate genomes.
Tomoya Kotani, Associate Professor
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The Kotani Lab studies how a fertilized egg develops into an individual, using maternal factors as a starting point. More than 10,000 kinds of factors are stored in the oocyte, and fertilization and the development that follows proceed through their actions. Using zebrafish and mice, the lab investigates when and where maternal factors act, and how they are regulated. Using a technology that visualizes mRNA with high sensitivity, the lab tracks the structures mRNA takes in the cytoplasm and the switching of translation.
Katsueki Ogiwara, Associate Professor
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The Ogiwara Group studies how the ovary works, starting from the proteins involved in reproduction. The group raises its own medaka and mice and investigates, at the molecular level, the mechanism of ovulation, in which eggs are released from the ovary. Its subjects also include how the wound left after ovulation heals, and how the follicle that will grow is selected from among many follicles. Many questions in reproductive biology remain unanswered, and this field provides a foundation for applications such as reproductive medicine.
Shusei Mizushima, Associate Professor
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The Mizushima Lab studies the mechanism of fertilization in birds and genetic engineering techniques for birds that make use of that mechanism. In bird fertilization, polyspermy occurs, in which dozens of sperm enter a single egg. The lab has shown that stimulation by multiple sperm is required for embryonic development to begin. Currently, using quail and molecular biology methods, the lab is investigating how fertilization is involved in the origin of germ cells.
Shigeyuki Koshikawa, Professor
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The Koshikawa Lab conducts research that connects the lives of organisms in the wild to the evolution of developmental mechanisms. With the keyword Eco-Evo-Devo (ecology, evolution, and development), it works mainly with insects. The lab investigates how the wing and body patterns of the fruit fly Drosophila guttifera are formed and what roles they serve. It also studies the adaptation of blind ground beetles, which live in shallow underground layers and are thought to have lost their vision.
Shunsuke Utsumi, Professor
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The Utsumi Lab studies how connections among living things come about and how they change. From the standpoint of evolutionary community ecology, which combines community ecology and evolutionary biology, the lab mainly uses plants and insects as study subjects. Combining fieldwork and experiments with genome analysis, the lab works in the familiar natural environments of Hokkaido. The research extends to points of contact with human society, such as evolution in cities, ecosystem restoration, and the relationship between forests and farmland.
Takashi Hayakawa, Assistant Professor
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The Hayakawa Lab studies the genetic mechanisms underlying the behavior, ecology, and evolution of wild animals. By combining field observation and surveys with genome analysis, the lab studies wild animals from a genomic perspective. The animals it studies range widely, including chimpanzees, Japanese macaques, koalas, echidnas, brown bears, and whales. The lab places importance on non-invasive methods, such as collecting DNA from feces without harming the animals.
Yasuhiro Sato, Assistant Professor
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The Quantitative Ecological Genetics Lab untangles ecological phenomena surrounding plants using bioinformatics techniques. Responses to the environment and interactions among organisms in the field are complex traits that involve quantitative differences. Using omics science and statistical methods, the lab seeks to understand the genetic basis behind these traits quantitatively. The lab mainly works with plants such as Arabidopsis thaliana and Arabidopsis halleri, and with the leaf beetles that feed on them.
Kiyohito Yoshida, Assistant (Joshu)
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The Yoshida Lab studies the functions of long-chain polyunsaturated fatty acids (LC-PUFAs) such as DHA and EPA. Because LC-PUFAs have many double bonds, they tend to take a bent shape and are thought to play a role in maintaining the fluidity of cell membranes. The lab aims to discover physiological functions that are not yet known and to clarify their mechanisms at the molecular level. It also carries out practical research on getting microorganisms to produce LC-PUFAs efficiently.
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