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Reproductive and Developmental Biology Lab, Ogiwara Group
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The lab works to uncover how eggs are selected and released from the ovary.
AboutAbout the lab
Exploring the mysteries of life through proteins and genes
The Ogiwara Group studies how the ovary works, starting from the proteins involved in reproduction.
The group raises its own medaka and mice and investigates, at the molecular level, the mechanism of ovulation, in which eggs are released from the ovary.
Its subjects also include how the wound left after ovulation heals, and how the follicle that will grow is selected from among many follicles.
Many questions in reproductive biology remain unanswered, and this field provides a foundation for applications such as reproductive medicine.
Key terms
- Ovulation
- The local dissolving of the membrane covering the ovary, through which the egg is released out of the ovary
- Follicle
- A sac-like structure in the ovary that surrounds the precursor of an egg. Ovulation occurs from a follicle that has grown
- Oocyte maturation
- The process in which an egg in the ovary completes its development until it becomes capable of being fertilized
ResearchResearch themes
The lab aims to understand ovarian function by clarifying how proteins involved in reproduction work. Using medaka and mice, it addresses ovulation, tissue repair, oocyte maturation, and follicle selection.
*Illustrative imageSearching for the ovulatory enzyme in mammals
During ovulation, the tough outer wall covering the ovary dissolves locally. Based on information about the ovulatory enzyme found in medaka, the lab is searching in mice for the mammalian ovulatory enzyme, which has not yet been found.
*Illustrative imageTissue repair after ovulation
A medaka lays 20 to 30 eggs in a single ovulation, and the ovary is left with that many holes. Even so, it ovulates again 24 hours later, so the lab is investigating the mechanism of this rapid tissue repair.
*Illustrative imageCommunication between ovulation and oocyte maturation
Fertilization takes place because an egg that has become capable of being fertilized is ovulated, so some kind of communication is thought to exist between oocyte maturation and ovulation. The lab is trying to clarify this at the molecular level.
*Illustrative imageHow are growing follicles selected?
The ovary stores a large number of primordial follicles, the precursors of eggs, and from among them, some begin to grow and some of those are then selected for ovulation. The lab is investigating the mechanism of this selection.
MembersFaculty
The members of the Ogiwara Group are faculty and students in the doctoral, master's, and undergraduate programs.As of 2025
- Associate ProfessorKatsueki Ogiwara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Oryzias latipes(Hamamatsu,Shizuoka,Japan,2007)-1” Seotaro / CC BY-SA 3.0 (cropped)
- Searching for the ovulatory enzyme in mammals: “Agouti Mice” Randy Jirtle and Dana Dolinoy / CC BY 3.0 (cropped)
- Tissue repair after ovulation: “Medaka (Oryzias latipes) egg, day 0” Ethmostigmus / CC BY-SA 4.0 (cropped)
- Communication between ovulation and oocyte maturation: “Ovarian follicle” TiagoLubiana / CC BY-SA 4.0 (cropped)
- How are growing follicles selected?: “Thomas Bresson - Ovaire-lapin (by)” Thomas Bresson / CC BY 2.0 (cropped)
- Related lab (Kimura-Fujimori Lab): “Black-mouse-trio-in-cage-2” Commissioned by Understanding Animal Research / CC BY-SA 4.0 (cropped)
- Related lab (Yoshida Lab): “Docosahexaenoic-acid-3D-sf” Ben Mills / Public domain (cropped)
- Related lab (Morphology and Function II Lab): “Arabidopsis thal kz1” Krzysztof Ziarnek, Kenraiz / CC BY-SA 3.0 (cropped)
- Related lab (Tanaka Lab): “Drosophila melanogaster 53362116” Alexis / CC BY 4.0 (cropped)
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