Labs in Hokkaido University, School of Pharmaceutical Sciences, Department of Pharmaceutical Sciences and Department of Pharmacy

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The lab uses molecular imaging to see, diagnose, and control life.

The Bioanalytical Chemistry Lab studies molecular imaging, which visualizes specific molecules inside the body. By seeing and diagnosing life, the lab works to elucidate the causes of disease and to develop methods for early detection and early treatment. For control, it creates drugs that are activated at specific sites in the body, and methods to freely control compounds inside the body. Its main tools are nuclear medicine, which uses radioisotopes, and light such as fluorescence and X-rays.

#Molecular imaging #Nuclear medicine #Optical imaging

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A lab for patient-centered clinical pharmaceutics, studying how to use medicines safely and correctly.

The Clinical Pharmaceutics Lab studies how medicines can be used safely. The lab investigates ways to avoid side effects of medicines, as well as interactions between drugs and between drugs and food components. Its ultimate goal is to deliver information on medicines and healthcare so that all patients can receive equally high-quality medical care.

#Clinical pharmaceutics #Pharmacokinetics #Drug-drug interactions

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A lab developing regenerative medicine that uses cells as drugs, along with new therapies.

The Molecular and Cellular Pharmaceutical Sciences Lab conducts research on regenerative medicine with the goal of "using cells as drugs." Mesenchymal stem cells are isolated from the amniotic membrane, which is normally discarded after childbirth, and their effects and mechanisms are examined in various disease models. The lab also works on regenerative medicine using periodontal ligament stem cells and CAR-T cells, therapies using bioabsorbable materials, and elucidating how Kampo (traditional Japanese herbal) medicines work.

#Regenerative medicine #Mesenchymal stem cells #Cell therapy

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A lab that studies how drugs move through the body, leading to safe drug therapy.

The Pharmacokinetic Analysis Lab studies how drugs that enter the body are absorbed, distributed, metabolized, and excreted (pharmacokinetics). The lab aims to provide information for giving the right dose of a drug to the right patient and delivering safer drug therapy. The professor and associate professor also hold positions in the Department of Pharmacy at Hokkaido University Hospital, and clinical research is carried out jointly with the hospital and other institutions.

#Pharmacokinetics #Transporters #TDM

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The lab creates new molecular catalysts to control chemical reactions at will.

The Uraguchi Lab studies how to control chemical reactions by using molecules that have never existed before as catalysts. To efficiently supply the organic molecules that support our daily lives, such as pharmaceuticals, agrochemicals, and plastics, it is necessary to understand and control the chemical reactions that join molecules together. The lab draws out the catalytic power inherent in molecular structures and takes on the challenge of freely controlling the reactive species involved in reactions (anions, radicals, and cations). The lab is part of the Division of Molecular Catalysis at the Institute for Catalysis, and third-year students of the Faculty of Pharmaceutical Sciences are also assigned to it.

#Molecular catalysts #Control of reactive species #Selective modification of biomolecules

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The lab investigates the three-dimensional structures that the genome forms inside the nucleus and the roles they play.

The Genome Medical Biology Lab studies the three-dimensional structures that the genome forms inside the nucleus, and the roles those structures play in biological phenomena. Genome structure is closely linked to transcription and to DNA replication and repair, and its disruption is known to be involved in cancer and developmental disorders. Using cultured human cells and fission yeast, the lab combines genomics based on next-generation sequencing with genetics, cell biology, and biochemistry. Professor Noma is a cross-appointed professor who runs labs at both Hokkaido University and the University of Oregon in the United States, and responds to students while staying in constant contact with Associate Professor Ohta.

#3D genome structure #Condensin #Cellular senescence

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The lab explores how cells process signals and turn them into responses.

The Molecular Cell Biology Lab studies how cells process the various signals they receive and turn them into responses. The lab approaches this question from the perspectives of post-translational modification and localization control of proteins, and communication between organelles. The lab also conducts research on new functional links between nerves and the immune system in the brain, and on neuroethology using the fruit fly Drosophila melanogaster. Graduate students can join through the Life and Pharmaceutical Sciences Course in the Department of Life Science at the Graduate School of Life Science.

#Antiviral response #Post-translational modification #Inter-organelle communication

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The lab investigates how infection with Helicobacter pylori leads to gastric cancer.

The Infection and Oncology Lab studies the mechanisms by which H. pylori infection triggers gastric cancer. Among H. pylori strains, those carrying the cagA gene are the ones involved in the development of gastric cancer. The CagA protein produced by the bacteria is injected into gastric epithelial cells, where it binds to molecules inside the cells and is thought to promote their transformation into cancer cells. The lab belongs to the Division of Pathophysiology at the Institute for Genetic Medicine, and Associate Professor Kamiya also serves as a faculty member of the institute's affiliated Center for Infection-Associated Cancer.

#Helicobacter pylori #Gastric cancer #CagA

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有機合成医薬学部門（創薬科学研究教育センター） (introduction coming soon)

Synthetic organic chemistry, chemical synthesis of natural products, nucleic acids, and peptides, drug discovery science, chemical biology