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Molecular and Cellular Pharmaceutical Sciences Lab
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A lab developing regenerative medicine that uses cells as drugs, along with new therapies.
AboutAbout the lab
Using cells as medicine.
The Molecular and Cellular Pharmaceutical Sciences Lab conducts research on regenerative medicine with the goal of "using cells as drugs."
Mesenchymal stem cells are isolated from the amniotic membrane, which is normally discarded after childbirth, and their effects and mechanisms are examined in various disease models.
The lab also works on regenerative medicine using periodontal ligament stem cells and CAR-T cells, therapies using bioabsorbable materials, and elucidating how Kampo (traditional Japanese herbal) medicines work.
Key terms
- Mesenchymal stem cells
- Stem cells that can turn into various cell types such as bone and fat. They are attracting attention as a material for regenerative medicine
- Amniotic membrane
- A thin membrane that surrounds the baby in the womb. It is usually discarded after childbirth
- Bioabsorbable materials
- Materials that are gradually broken down and absorbed over time once placed in the body
NewsLab news
A student received the Excellent Presentation Award at the 43rd Annual Meeting of the Society for Wakan-Yaku
A master's student received the Excellent Presentation Award at the 24th General Assembly of the Japanese Society for Regenerative Medicine
Results of a multicenter clinical trial of a Kampo medicine conducted by Professor Ohnishi accepted by Integr Cancer Ther
A doctoral student received the Young Investigator Excellent Presentation Award at the 37th General Meeting of the Research Society for Substitute Organs and Regenerative Medicine
A student received the Young Researcher Excellent Presentation Award at the 37th Hokkaido Symposium on Drug Action
ResearchResearch themes
The lab conducts research and development in regenerative medicine with the goal of "using cells as drugs." Alongside stem cell therapies, it also studies bioabsorbable materials, cancer stem cells, and Kampo medicines, aiming for clinical application.
*Illustrative imageRegenerative medicine using amniotic stem cells
The lab has established a method to isolate and expand mesenchymal stem cells in large quantities at high purity from the amniotic membrane discarded at childbirth. It confirms their effects in animal models of diseases such as inflammatory bowel disease and liver cirrhosis, and is working to elucidate their mechanisms of action.
*Illustrative imageRegenerative medicine that makes use of periodontal tissue
The lab isolates and cultures stem cells from the periodontal ligament, which has a strong capacity for regeneration, and examines whether they can be used in tissue regenerative medicine. It is also developing a graft material that aids tissue regeneration by taking advantage of the countless fine tubules (dentinal tubules) in the dentin of tooth roots.
*Illustrative imageRegenerative medicine with bioabsorbable materials
Together with companies, the lab develops bioabsorbable materials to prevent or treat bleeding, perforation, and stricture of the digestive tract that occur after endoscopic resection of conditions such as gastric cancer.
*Illustrative imageCell therapy to suppress liver fibrosis
Once liver cirrhosis progresses, liver transplantation is the only treatment. The lab is developing a new cell therapy to suppress liver fibrosis, the hardening of the liver.
MembersFaculty
The Molecular and Cellular Pharmaceutical Sciences Lab consists of faculty members, a professor emeritus, students in the doctoral, master's, and undergraduate programs, researchers, and administrative assistants.As of 2026
- ProfessorSyunsuke Ohnishi
- LecturerNaoto Okubo
- Assistant ProfessorOsamu Maehara
- Assistant ProfessorAtushi Tsuge
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “1 msc DAPI+ThR001 a” OlgaMaslova / CC BY-SA 4.0 (cropped)
- Regenerative medicine using amniotic stem cells: “Mesenchymal Stem Cell” Robert M. Hunt / CC BY 3.0 (cropped)
- Regenerative medicine that makes use of periodontal tissue: “Tooth line diagram with periodontal ligament” Ian Furst / CC BY-SA 4.0 (cropped)
- Regenerative medicine with bioabsorbable materials: “Flexibles Endoskop” de:Benutzer:Kalumet / CC BY-SA 3.0 (cropped)
- Cell therapy to suppress liver fibrosis: “Cirrhosis of the liver (trichrome stain) ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Drug Molecular Design Lab): “Generic Drug Research ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Related lab (Precision Synthetic Chemistry Lab): “CSIRO ScienceImage 10606 High vacuum apparatus” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (Clinical Pharmaceutics Lab): “Robot de distribution” Sandra Culand / CC BY-SA 4.0 (cropped)
- Related lab (Health Chemistry Lab): “Ileum biopsy with lymphoid tissue, intermed. mag” CoRus13 / CC BY-SA 4.0 (cropped)
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