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Pharmacokinetic Analysis Lab
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A lab that studies how drugs move through the body, leading to safe drug therapy.
AboutAbout the lab
Safe drug therapy, based on drug pharmacokinetics.
The Pharmacokinetic Analysis Lab studies how drugs that enter the body are absorbed, distributed, metabolized, and excreted (pharmacokinetics).
The lab aims to provide information for giving the right dose of a drug to the right patient and delivering safer drug therapy.
The professor and associate professor also hold positions in the Department of Pharmacy at Hokkaido University Hospital, and clinical research is carried out jointly with the hospital and other institutions.
Key terms
- Pharmacokinetics
- The movement of a drug after it enters the body: absorption, distribution, metabolism, and excretion
- Transporter
- A protein in the cell membrane that carries substances such as drugs and nutrients into and out of cells
- Enteroid
- A small three-dimensional tissue grown from small intestinal stem cells that mimics the intestinal epithelium
- Insurance claim (receipt)
- An itemized statement of medical fees that a medical institution submits to the insurer. It records which drugs were prescribed
NewsLab news
Paper by a doctoral student (working professional) published in Jpn J Clin Oncol.
Assistant Professor Nashimoto received the Academic Encouragement Award from the Japanese Society of Chemotherapy
Paper by a doctoral student (working professional) published in Pharmacotherapy
Paper by a doctoral student (working professional) published in Infection Control and Hospital Epidemiology
Paper by Assistant Professor Nashimoto published in European Journal of Clinical Pharmacology
ResearchResearch themes
The lab studies the mechanisms by which administered drugs are absorbed from the gastrointestinal tract, distributed to organs, and metabolized and excreted. By clarifying drug transport in the small intestine and kidney and the reasons blood drug concentrations differ between individuals, it aims to lead to dosing regimens tailored to each patient.
*Illustrative imageTransporter function and pharmacokinetics
Using enteroids grown from small intestinal stem cells, the lab is building a new experimental system to evaluate the function of transporters that pump drugs out of cells. A distinctive feature is that changes can be observed visually with a fluorescence microscope.
*Illustrative imageFormulation approaches to improve absorption
The lab clarifies how poorly absorbed components of functional foods are absorbed from the gastrointestinal tract and designs optimal dosage forms. It also identifies interactions between drugs and food components and proposes ways to avoid them.
*Illustrative imagePlatelet activation and pharmacokinetics
The lab analyzes whether platelets, which are involved in hemostasis and thrombus formation, alter the transport activity of transporters that play a major role in drug absorption.
*Illustrative imagePharmacoepidemiology using healthcare data
Together with Hokkaido University Hospital and other institutions, the lab has created tools such as a flowchart for initial dosing of vancomycin, an anti-MRSA drug, to avoid its side effects. Using large-scale insurance claims databases, it also analyzes how drugs are used in actual clinical practice and their risks.
MembersFaculty
The Pharmacokinetic Analysis Lab consists of faculty members, students in the doctoral (including working professionals), master's, and undergraduate programs, and research students.As of 2026
- ProfessorMitsuru Sugawara
- Associate ProfessorYoh Takekuma
- LecturerHitoshi Kashiwagi
- LecturerYuki Sato
- Assistant ProfessorShunsuke Nashimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “SI organoid 1” Abhimanu.pandey / CC BY 4.0 (cropped)
- Transporter function and pharmacokinetics: “Organoïde intestinal” Paul Barreau / CC BY-SA 4.0 (cropped)
- Formulation approaches to improve absorption: “Omega 3 capsules in white bottle ( )” Jernej Furman from Slovenia / CC BY 2.0 (cropped)
- Platelet activation and pharmacokinetics: “Blausen 0740 Platelets” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Pharmacoepidemiology using healthcare data: “Vancomycin-from-xtal-1996-3D-balls” Ben Mills / Public domain (cropped)
- Related lab (臨床薬剤学研究室): “Robot de distribution” Sandra Culand / CC BY-SA 4.0 (cropped)
- Related lab (遺伝子病制御研究所 病態研究部門 感染腫瘍学分野): “Ulcer-causing Bacterium (H.Pylori) Crossing Mucus Layer of Stomach” Illustration Credit: Zina Deretsky, National Science Foundation / Public domain (cropped)
- Related lab (天然物化学研究室): “Esponja (Theonella swinhoei), Anilao, Filipinas, , DD 67” Diego Delso / CC BY-SA 4.0 (cropped)
- Related lab (未来創剤学研究室): “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image 2” Erin Rod / CC BY 4.0 (cropped)
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